ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Rapid and Bihemispheric Reorganization of Neuronal Activity in Premotor Cortex after Brain Injury.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Mean Motor Disconnectivity Predicts Hand Function Impairment After Stroke: Beyond Motor Cortex Output.Stroke · 2026Trial
- Evaluation of a novel elbow joint torque measurement device in healthy subjects and stroke patients: a randomized trial.Scientific reports · 2025Trial
- Is there a correlation between functional recovery of manual dexterity after motor cortex lesion and initial motor learning slope in the intact state?Frontiers in systems neuroscience · 2026Article
- Re-Examination and Extension of Manual Dexterity Behavioral Data in M1 Lesioned Adult Macaque Monkeys: A Survey of Therapies Induced Enhancement of Functional Recovery.Neuroscience insights · 2026Article
- Qualitative and quantitative analysis of the callosal projections to prefrontal, frontal motor, and parietal areas in the macaque monkey.Brain structure & function · 2025Article
- Confirmation of the Enhancement Effect of ANCE Treatment on Functional Recovery of Manual Dexterity From Primary Motor Cortex (M1) Lesion in Adult Macaque Monkeys.Brain and behavior · 2025Article
- Characterization of responders to transcranial direct current stimulation in disorders of consciousness: A retrospective study of 8 clinical trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Interactive dynamic scalp acupuncture enhances brain functional connectivity in bilateral basal ganglia ischemic stroke patients: a randomized controlled trial.Frontiers in neurology · 2025Article
- Article
- Differential Modulation of Local Field Potentials in the Primary and Premotor Cortices during Ipsilateral and Contralateral Reach to Grasp in Macaque Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Porcine Model of Cerebral Ischemic Stroke Utilizing Intracortical Recordings for the Continuous Monitoring of the Ischemic Area.Sensors (Basel, Switzerland) · 2024Article
- Autonomous optimization of neuroprosthetic stimulation parameters that drive the motor cortex and spinal cord outputs in rats and monkeys.Cell reports. Medicine · 2023Article
- Brain Asymmetry and Its Effects on Gait Strategies in Hemiplegic Patients: New Rehabilitative Conceptions.Brain sciences · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Brain injuries cause hemodynamic changes in several distant, spared areas from the lesion. Our objective was to better understand the neuronal correlates of this reorganization in awake, behaving female monkeys. We used reversible inactivation techniques to "injure" the primary motor cortex, while continuously recording neuronal activity of the ventral premotor cortex in the two hemispheres, before and after the onset of behavioral impairments. Inactivation rapidly induced profound alterations of neuronal discharges that were heterogeneous within each and across the two hemispheres, occurred during movements of either the affected or nonaffected arm, and varied during different phases of grasping. Our results support that extensive, and much more complex than expected, neuronal reorganization takes place in spared areas of the bihemispheric cortical network involved in the control of hand movements. This broad pattern of reorganization offers potential targets that should be considered for the development of neuromodulation protocols applied early after brain injury.
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Registered trials
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