Evidence map›Paper›PMID 34556478›Full record

ArticleAJNR. American journal of neuroradiology2021

MR Imaging Differences in the Circle of Willis between Healthy Children and Adults.

K P Guilliams, N Gupta, S Srinivasan, M M Binkley, C Ying, L Couture, J Gross, A Wallace, R C McKinstry, K Vo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

K P GuilliamsFrom the Department of Neurology (K.P.G., M.M.B., J.-M.L., M.S.G.).ORCID 0000-0002-5518-3778
N GuptaMallinckrodt Institute of Radiology (K.P.G., N.G., S.S., C.Y., L.C., R.C.M., K.V., J.-M.L., H.A., M.S.G.).ORCID 0000-0002-1377-0181
S SrinivasanMallinckrodt Institute of Radiology (K.P.G., N.G., S.S., C.Y., L.C., R.C.M., K.V., J.-M.L., H.A., M.S.G.).ORCID 0000-0001-8951-3213
M M BinkleyFrom the Department of Neurology (K.P.G., M.M.B., J.-M.L., M.S.G.).ORCID 0000-0002-7701-7615
C YingMallinckrodt Institute of Radiology (K.P.G., N.G., S.S., C.Y., L.C., R.C.M., K.V., J.-M.L., H.A., M.S.G.).ORCID 0000-0003-1060-3289
L CoutureMallinckrodt Institute of Radiology (K.P.G., N.G., S.S., C.Y., L.C., R.C.M., K.V., J.-M.L., H.A., M.S.G.).
J GrossDivision of Neuroradiology (J.G.), Midwest Radiology, St. Paul, Minnesota.ORCID 0000-0002-4794-8232
A WallaceDepartment of Neurointerventional Surgery (A.W.), Ascension Columbia St. Mary's Hospital, Milwaukee, Wisconsin.ORCID 0000-0002-0450-8464
R C McKinstryDepartment of Pediatrics (K.P.G., R.C.M.).ORCID 0000-0003-3578-4899
K VoMallinckrodt Institute of Radiology (K.P.G., N.G., S.S., C.Y., L.C., R.C.M., K.V., J.-M.L., H.A., M.S.G.).ORCID 0000-0002-9318-4253
J-M LeeFrom the Department of Neurology (K.P.G., M.M.B., J.-M.L., M.S.G.).ORCID 0000-0002-3979-0906
H AnMallinckrodt Institute of Radiology (K.P.G., N.G., S.S., C.Y., L.C., R.C.M., K.V., J.-M.L., H.A., M.S.G.).ORCID 0000-0001-6459-2269
M S GoyalFrom the Department of Neurology (K.P.G., M.M.B., J.-M.L., M.S.G.) goyalm@wustl.edu.ORCID 0000-0003-1970-4270

Funding

Aerobic Glycolysis: A Marker of BrainResilience to Aging and Alzheimer's DiseaseR01AG057536 · NIA · WASHINGTON UNIVERSITY · PI GOYAL, MANU S, VLASSENKO, ANDREI G. · 2017 to 2021
$3.7M
Age-Dependence of Cerebral Oxygen Metabolism and Stroke Risk in Pediatric Sickle Cell DiseaseK23NS099472 · NINDS · WASHINGTON UNIVERSITY · PI GUILLIAMS, KRISTIN · 2017 to 2021
$951k
NIA NIH HHS R01 AG057536NINDS NIH HHS K23 NS099472
6 · The paper itself

Abstract

background and purposeAsymmetries in the circle of Willis have been associated with several conditions, including migraines and stroke, but they may also be age-dependent. This study examined the impact of age and age-dependent changes in cerebral perfusion on circle of Willis anatomy in healthy children and adults. MATERIALS AND

methodsWe performed an observational, cross-sectional study of bright and black-blood imaging of the proximal cerebral vasculature using TOF-MRA and T2 sampling perfection with application-optimized contrasts by using different flip angle evolution (T2-SPACE) imaging at the level of the circle of Willis in 23 healthy children and 43 healthy adults (4-74 years of age). We compared arterial diameters measured manually and cerebral perfusion via pseudocontinuous arterial spin-labeling between children and adults.

resultsWe found that the summed cross-sectional area of the circle of Willis is larger in children than in adults, though the effect size was smaller with T2-SPACE-based measurements than with TOF-MRA. The circle of Willis is also more symmetric in children, and nonvisualized segments occur more frequently in adults than in children. Moreover, the size and symmetry of the circle of Willis correlate with cerebral perfusion.

conclusionsOur results demonstrate that the circle of Willis is different in size and symmetry in healthy children compared with adults, likely associated with developmental changes in cerebral perfusion. Further work is needed to understand why asymmetric vasculature develops in some but not all adults.

Indexed as

Circle of WillisMagnetic Resonance AngiographyAdultChildCross-Sectional StudiesHumansMagnetic Resonance ImagingSpin LabelsSpin Labels

Identifiers

PMID34556478
PMCPMC8583273

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.