Evidence map›Paper›PMID 34556392›Full record

ReviewTrends in biochemical sciences2022

Coupling lipid synthesis with nuclear envelope remodeling.

Sarah R Barger, Lauren Penfield, Shirin Bahmanyar

Open access · greenAbstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. The Inner Nuclear Membrane Has a Unique Lipid Signature.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The cell biology of ferroptosis.Nature reviews. Molecular cell biology · 2024
    Review
  15. Article
  16. Phosphatidic acid signaling and function in nuclei.Progress in lipid research · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sarah R BargerDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA.
Lauren PenfieldDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA.
Shirin BahmanyarDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA. Electronic address: shirin.bahmanyar@yale.edu.
Yale University · US

Funding

Defining the role of lipid metabolism in nuclear envelope identity and dynamicsR01GM131004 · NIGMS · YALE UNIVERSITY · PI Shirin Bahmanyar · 2019 to 2026
$2.8M
NIGMS NIH HHS R01 GM131004
6 · The paper itself

Abstract

The nuclear envelope (NE) is a protective barrier to the genome, yet its membranes undergo highly dynamic remodeling processes that are necessary for cell growth and maintenance. While mechanisms by which proteins promote NE remodeling are emerging, the types of bilayer lipids and the lipid-protein interactions that define and sculpt nuclear membranes remain elusive. The NE is continuous with the endoplasmic reticulum (ER) and recent evidence suggests that lipids produced in the ER are harnessed to remodel nuclear membranes. In this review, we examine new roles for lipid species made proximally within the ER and locally at the NE to control NE dynamics. We further explore how the biosynthesis of lipids coordinates NE remodeling to ensure genome protection.

Indexed as

Endoplasmic ReticulumNuclear EnvelopeCell CycleLipidsLipidsCTDNEP1diacylglycerolendoplasmic reticulumESCRTinner nuclear membranelipid synthesislipinNem1nuclear envelopenuclear envelope remodelingphosphatidic acid

Identifiers

PMID34556392
PMCPMC9943564
OpenAlexW3200774790

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.