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ArticleTransplantation proceedings2021

Is Early COVID-19 in Kidney Transplant Recipients Concerning Enough to Halt Transplantation? A Multicenter Comparative Analysis from India.

Hari Shankar Meshram, Vivek B Kute, Himanshu V Patel, Umapati Hegde, Pratik Das, Keshab Sil, Manisha Sahay, Sree Bhushan Raju, Arpita Ray Chaudhury, Vishwanath Siddini and 8 more

Abstract readMulticenter Study
In one paragraph

Article in Transplantation proceedings, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hari Shankar MeshramDepartment of Nephrology, Institute of Kidney Diseases and Research Centre, Dr. H. L. Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.
Vivek B KuteDepartment of Nephrology, Institute of Kidney Diseases and Research Centre, Dr. H. L. Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India. Electronic address: drvivekkute@rediffmail.com.
Himanshu V PatelDepartment of Nephrology, Institute of Kidney Diseases and Research Centre, Dr. H. L. Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.
Umapati HegdeDepartment of Nephrology, Muljibhai Patel Urological Hospital, Nadiad, Gujarat, India.
Pratik DasDepartment of Nephrology, Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, West Bengal.
Keshab SilDepartment of Nephrology, Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, West Bengal.
Manisha SahayDepartment of Nephrology, Osmania General Hospital, Hyderabad, India.
Sree Bhushan RajuDepartment of Nephrology, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, India.
Arpita Ray ChaudhuryDepartment of Nephrology, Institute of Post-Graduate Medical Education & Research, Kolkata, India.
Vishwanath SiddiniDepartment of Nephrology, Manipal Hospital, Bangalore, India.
Vivek PathakDepartment of Nephrology, Kovai Medical Centre and Hospital, Coimbatore, Tamil Nadu, India.
M M BahadurDepartment of Nephrology, Jaslok Hospitals, Mumbai, India.
Urmila AnandDepartmentt of Nephrology, Centre Yashoda Hospitals, Secunderabad, India.
Amresh KrishnaDepartment of Nephrology and Renal Transplantation, Indira Gandhi Institute of Medical Science, Patna, India.
Abi AbrahamLakeshore Hospital, Kochi, Kerala, India.
Ansy H PatelB. J. Medical Hospital, Civil Hospital, Ahmedabad, Gujarat, India.
Vineet MishraDepartment of Gynecology, Institute of Kidney Diseases and Research Centre, Dr. H. L. Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.
Sanshriti ChauhanDepartment of Nephrology, Institute of Kidney Diseases and Research Centre, Dr. H. L. Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLimited data exist on the incidence and outcome of early coronavirus disease 2019 (COVID-19) in kidney transplantation recipients (KTR).

methodsA retrospective multicenter research study was conducted across 12 centers in India. We explored the symptomatology, demographic, laboratory findings, and outcome of COVID-19 within 30 days of transplantation. The outcome was compared with the overall KTR and waitlisted patients acquiring COVID-19.

resultsThe incidence of early COVID-19 was 2.6% (n = 22) for the cumulative 838 renal transplants performed since nationwide lockdown in March 2020 until May 2021. Overall, 1049 KTR were diagnosed with COVID-19 and 2% of those had early COVID-19. The median age of the early COVID-19 cohort was 43 (31-46) years. COVID-19 severity ranged from asymptomatic (18.2%), mild (59.1%), moderate (9.1%), and severe (13.6%). Among clinical symptoms, dyspnea and anosmia were frequent, and in laboratory parameters, neutrophil lymphocyte ratio, high-sensitivity C-reactive protein, and D-dimer were higher in patients requiring oxygen. The mortality in early COVID-19 was not higher than overall KTR (4.5% vs 8.5%; P = 1). COVID-19 severity (23.9% vs 15.7%; P = .0001) and mortality (15.5% vs 8.5%; P = .001) among waitlisted patients (n = 1703) were higher compared with overall KTR.

conclusionsWe report higher burden of COVID-19 in waitlisted patients compared with KTR and a favorable outcome in early COVID-19 in KTR. Our report will help the transplant physicians in dealing with the ongoing dilemma of halting or resuming transplantation in the COVID-19 era.

Indexed as

COVID-19Kidney TransplantationTransplant RecipientsAdultCommunicable Disease ControlFemaleHumansIndiaMaleMiddle AgedRetrospective Studies

Identifiers

PMID34556343
PMCPMC8403672

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