Evidence map›Paper›PMID 34556105›Full record

ArticleBMC musculoskeletal disorders2021

Peripheral quantitative computed tomography in the assessment of bone mineral density in anti-TNF-treated rheumatoid arthritis and ankylosing spondylitis patients.

Balázs Juhász, Katalin Gulyás, Ágnes Horváth, Edit Végh, Anita Pusztai, Ágnes Szentpétery, Zsófia Pethő, Nóra Bodnár, Attila Hamar, Levente Bodoki and 12 more

Open access · goldAbstract read
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In one paragraph

Article in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Treatment of glucocorticoid-induced osteoporosis with concurrent denosumab and romosozumab: a case report.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 3 countries.

Balázs JuhászDepartment of Oncology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Katalin GulyásDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Ágnes HorváthDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Edit VéghDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Anita PusztaiDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Ágnes SzentpéteryDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Zsófia PethőDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Nóra BodnárDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Attila HamarDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Levente BodokiDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Harjit Pal BhattoaDepartment of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Éva SzekaneczDepartment of Oncology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Katalin HodosiDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Andrea DomjánDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Szilvia SzamosiDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Csaba HorváthFirst Department of Medicine, Semmelweis University, Budapest, Hungary.
Sándor SzántóDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Gabriella SzűcsDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary.
Hennie G RatermanDepartment of Rheumatology, Northwest Clinics, Alkmaar, The Netherlands.
Willem F LemsAmsterdam Rheumatology and Immunology Centre, Amsterdam, The Netherlands.
Oliver FitzGeraldConway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland.
Zoltán SzekaneczDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei str. 98, Debrecen, 4032, Hungary. szekanecz.zoltan@med.unideb.hu.
University of Debrecen · HUUniversity College Dublin · IESemmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRheumatoid arthritis (RA) and ankylosing spondylitis (AS) are associated with osteoporosis. There have not been many peripheral quantitative computed tomography (QCT) studies in patients receiving biologics. We assessed volumetric and areal bone mineral density (BMD) by forearm QCT and dual-energy X-ray absorptiometry (DXA), respectively in addition to laboratory biomarkers in these arthritides.

methodsForty RA and AS patients treated with either etanercept (ETN) or certolizumab pegol (CZP) were undergoing follow-ups for one year. Volumetric and areal BMD, as well as parathyroid hormone (PTH), osteocalcin, RANKL, 25-hydroxyvitamin D (VITD), P1NP, CTX, sclerostin (SOST), Dickkopf 1 (DKK-1) and cathepsin K (CATHK) were determined.

resultsWe did not observe any further bone loss during the 12-month treatment period. Volumetric and areal BMD showed significant correlations with each other (p<0.017 after Bonferroni's correction). Trabecular QCT BMD at baseline (p=0.015) and cortical QCT BMD after 12 months (p=0.005) were inversely determined by disease activity at baseline in the full cohort. Trabecular QCT BMD at baseline also correlated with CTX (p=0.011). In RA, CRP negatively (p=0.014), while SOST positively (p=0.013) correlated with different QCT parameters. In AS, RANKL at baseline (p=0.014) and after 12 months (p=0.007) correlated with cortical QCT BMD. In the full cohort, 12-month change in QTRABBMD was related to TNF inhibition together with elevated VITD-0 levels (p=0.031). Treatment and lower CATHK correlated with QCORTBMD changes (p=0.006). In RA, TNF inhibition together with VITD-0 (p<0.01) or CATHK-0 (p=0.002), while in AS, treatment and RANKL-0 (p<0.05) determined one-year changes in QCT BMD.

conclusionsBMD as determined by QCT did not change over one year of anti-TNF treatment. Disease activity, CATHK, RANKL and VITD may be associated with the effects of anti-TNF treatment on QCT BMD changes. RA and AS may differ in this respect.

Indexed as

Arthritis, RheumatoidSpondylitis, AnkylosingBone DensityHumansTomography, X-Ray ComputedTumor Necrosis Factor InhibitorsTumor Necrosis Factor InhibitorsAnkylosing spondylitisBiologicsBone densityOsteoporosisPeripheral quantitative computed tomographyRheumatoid arthritis

Identifiers

PMID34556105
PMCPMC8461899
OpenAlexW3201132761

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.