ArticleBMC ophthalmology2021
Ten-year epidemiological study of ocular and orbital tumors in Chiba University Hospital.
Article in BMC ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pattern of Orbito-ocular Tumours in Nigeria: a systematic review.BMC cancer · 2025Pooled it
- Histopathological spectrum of ocular masses in a tertiary eye center in Northern China: a 12-year retrospective analysis.Frontiers in medicine · 2026Article
- Identification of an efficient immunohistochemical panel for precise differential diagnosis of sebaceous carcinoma of eyelid.Discover oncology · 2025Article
- Clinical presentation and prognostic factors of eyelid sebaceous carcinoma.Japanese journal of ophthalmology · 2025Article
- A Systematic Review and Meta-Analysis of Ocular and Periocular Basal Cell Carcinoma with First-Time Description of Dermoscopic and Reflectance Confocal Microscopy Features of Caruncle Basal Cell Carcinoma.Diagnostics (Basel, Switzerland) · 2025Review
- Epidemiology of oculo-orbital tumours in Malawian children: a 10-year review of cases from tertiary hospitals.BMC ophthalmology · 2025Article
- Eyelid sebaceous gland carcinoma: a protocol for a systematic review and meta-analysis of clinicopathological studies of prevalence.BMJ open · 2024Article
- Squamous cell carcinoma of the eyelid.Japanese journal of clinical oncology · 2024Article
- Incidence and clinical characteristics of pediatric ocular tumors in a Midwestern US population.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2023Article
- Two Advancement Flaps for Eyelid Margin Reconstruction of Small and Medium Defects and a Novel Design to Reduce Ocular Injury.Clinical, cosmetic and investigational dermatology · 2023Article
- Local recurrence as extraocular muscle lymphoma after 6 years of chronic myositis: a case report.BMC ophthalmology · 2022Article
- Proteotranscriptomics of ocular adnexal B-cell lymphoma reveals an oncogenic role of alternative splicing and identifies a diagnostic marker.Journal of experimental & clinical cancer research : CR · 2022Article
- Utility of Precision Oncology Using Cancer Genomic Profiling for Head and Neck Malignancies.In vivo (Athens, Greece)Article
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6 authors.
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Abstract
backgroundThe purpose of this study is to determine the epidemiology of tumors of the ocular adnexa and orbit in Japan.
methodsWe conducted a retrospective study on the histopathological reports in the medical records of the Chiba University Hospital from April 2009 to March 2019. Three hundred and seventy two records were examined. In addition, we examined the annual changes in the major types of tumors including malignant lymphomas and IgG4-related diseases (IgG4-RDs).
resultsThere were 270 conjunctival or eyelid tumors with 166 benign and 104 malignant. There were 102 orbital tumors with 55 benign, 47 malignant tumors, and 21 cases of IgG4-RDs. Ten cases of adenoma (2.7%), another benign tumor, was also diagnosed. The major malignant tumors were malignant lymphoma in 74 cases, sebaceous gland carcinoma (SGC) in 28 cases, basal cell carcinoma in 15 cases, and squamous cell carcinoma in 8 cases. The SGCs were the most common malignant eyelid tumor at 54%. Among the malignant lymphomas, extranodal marginal zone lymphomas of the mucosa-associated lymphoid tissue type, MALT lymphomas, was the most common at 51 cases and the second most common was the diffuse large B-cell lymphoma at 11 cases. The ratio of MALT lymphomas to that of all malignant lymphomas increased significantly with years. The serum IgG4 values were measured more often in the last 5 years (70%) than in the former 5 years (33%).
conclusionsWe conclude that malignant lymphoma is a major malignant tumor in Japan and pathological biopsies should be done proactively to prevent missing IgG4-positive MALT lymphomas.
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