ArticleBMC musculoskeletal disorders2021
Which experimental procedures influence the apparent proximal femoral stiffness? A parametric study.
Article in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Decreased femoral fracture load after cephalomedullary nail removal : a biomechanical ex vivo study.Bone & joint research · 2025Article
- Microfilm Coatings: A Biomaterial-Based Strategy for Modulating Femoral Deflection.Journal of functional biomaterials · 2024Article
- The biomechanical behavior of 3D printed human femoral bones based on generic and patient-specific geometries.3D printing in medicine · 2022Article
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Authors and funding
4 authors.
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Abstract
backgroundExperimental validation is the gold standard for the development of FE predictive models of bone. Employing multiple loading directions could improve this process. To capture the correct directional response of a sample, the effect of all influential parameters should be systematically considered. This study aims to determine the impact of common experimental parameters on the proximal femur's apparent stiffness.
methodsTo that end, a parametric approach was taken to study the effects of: repetition, pre-loading, re-adjustment, re-fixation, storage, and μCT scanning as random sources of uncertainties, and loading direction as the controlled source of variation in both stand and side-fall configurations. Ten fresh-frozen proximal femoral specimens were prepared and tested with a novel setup in three consecutive sets of experiments. The neutral state and 15-degree abduction and adduction angles in both stance and fall configurations were tested for all samples and parameters. The apparent stiffness of the samples was measured using load-displacement data from the testing machine and validated against marker displacement data tracked by DIC cameras.
resultsAmong the sources of uncertainties, only the storage cycle affected the proximal femoral apparent stiffness significantly. The random effects of setup manipulation and intermittent μCT scanning were negligible. The 15
conclusionAccording to these results, comparisons between the stiffness of the samples under various loading scenarios can be made if there are no storage intervals between the different load cases on the same samples. These outcomes could be used as guidance in defining a highly repeatable and multi-directional experimental validation study protocol.
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