Evidence map›Paper›PMID 34556059›Full record

ArticleJournal of neurodevelopmental disorders2021

Effects of sensory distraction and salience priming on emotion identification in autism: an fMRI study.

Genevieve Patterson, Kaitlin K Cummings, Jiwon Jung, Nana J Okada, Nim Tottenham, Susan Y Bookheimer, Mirella Dapretto, Shulamite A Green

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurodevelopmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Sensory over-responsivity and atypical neural responses to socially relevant stimuli in autism.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  3. Bilingualism Predicts Affective Theory of Mind in Autistic Adults.Journal of speech, language, and hearing research : JSLHR · 2024
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Genevieve PattersonDepartment of Psychology, University of Denver, Denver, USA.
Kaitlin K CummingsJane and Terry Semel Institute of Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, USA.
Jiwon JungJane and Terry Semel Institute of Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, USA.
Nana J OkadaJane and Terry Semel Institute of Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, USA.
Nim TottenhamDepartment of Psychology, Columbia University, New York, USA.
Susan Y BookheimerJane and Terry Semel Institute of Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, USA.
Mirella DaprettoJane and Terry Semel Institute of Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, USA.
Shulamite A GreenJane and Terry Semel Institute of Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, USA. shulamite@ucla.edu.ORCID 0000-0003-4248-3576

Funding

Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
Parsing ASD Heterogeneity: Neuroendophenotypes of Social Attention and Sensory ResponsivityR01MH117982 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAPRETTO, MIRELLA, PELPHREY, KEVIN A · 2018 to 2023
$3.8M
Mechanisms underlying sensory over-responsivity in ASD and early adversityK08MH112871 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, SHULAMITE ABRA · 2017 to 2020
$798k
NIMH NIH HHS K08 MH112871NIMH NIH HHS K08MH112871NIMH NIH HHS R01MH100028NIMH NIH HHS R01MH117982
6 · The paper itself

Abstract

backgroundSocial interaction often occurs in noisy environments with many extraneous sensory stimuli. This is especially relevant for youth with autism spectrum disorders (ASD) who commonly experience sensory over-responsivity (SOR) in addition to social challenges. However, the relationship between SOR and social difficulties is still poorly understood and thus rarely addressed in interventions. This study investigated the effect of auditory sensory distracters on neural processing of emotion identification in youth with ASD and the effects of increasing attention to social cues by priming participants with their own emotional faces.

methodsWhile undergoing functional magnetic resonance imaging (fMRI), 30 youth with ASD and 24 typically developing (TD) age-matched controls (ages 8-17 years) identified faces as happy or angry with and without simultaneously hearing aversive environmental noises. Halfway through the task, participants also viewed videos of their own emotional faces. The relationship between parent-rated auditory SOR and brain responses during the task was also examined.

resultsDespite showing comparable behavioral performance on the task, ASD and TD youth demonstrated distinct patterns of neural activity. Compared to TD, ASD youth showed greater increases in amygdala, insula, and primary sensory regions when identifying emotions with noises compared to no sounds. After viewing videos of their own emotion faces, ASD youth showed greater increases in medial prefrontal cortex activation compared to TD youth. Within ASD youth, lower SOR was associated with reduced increased activity in subcortical regions after the prime and greater increased activity in the ventromedial prefrontal cortex after the prime, particularly in trials with noises.

conclusionsThe results suggest that the sensory environment plays an important role in how ASD youth process social information. Additionally, we demonstrated that increasing attention to relevant social cues helps ASD youth engage frontal regions involved in higher-order social cognition, a mechanism that could be targeted in interventions. Importantly, the effect of the intervention may depend on individual differences in SOR, supporting the importance of pre-screening youth for sensory challenges prior to social interventions.

Indexed as

Autism Spectrum DisorderAutistic DisorderAdolescentAmygdalaChildEmotionsHumansMagnetic Resonance ImagingAutismEmotionfMRISensory over-responsivitySensory processing

Identifiers

PMID34556059
PMCPMC8461948

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.