Evidence map›Paper›PMID 34555935›Full record

ArticleCirculation. Heart failure2021

Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8

William Bracamonte-Baran, Nisha A Gilotra, Taejoon Won, Katrina M Rodriguez, Monica V Talor, Byoung C Oh, Jan Griffin, Ilan Wittstein, Kavita Sharma, John Skinner and 7 more

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Article in Circulation. Heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Biochemistry and biophysics reports · 2026
    Review
  3. PD-1/PD-L1 Signaling in Non-ICI Myocarditis.JACC. Basic to translational science · 2026
    Article
  4. Review
  5. Article
  6. A call to redefine cardiovascular immunobiology around leukocyte plasticity.American journal of physiology. Heart and circulatory physiology · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Immune Checkpoint Inhibitor Therapy for Kidney Transplant Recipients - A Review of Potential Complications and Management Strategies.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

William Bracamonte-Baran *Department of Pathology, School of Medicine (W.B.-B., T.W., M.V.T., R.A.A., Q.Z., M.K.H., D.Č.), Johns Hopkins University, Baltimore, MD.
Nisha A Gilotra *Division of Cardiology, Department of Medicine, School of Medicine (N.A.G., J.G., I.W., K.S., S.D.R.), Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-4511-8008
Taejoon WonDepartment of Pathology, School of Medicine (W.B.-B., T.W., M.V.T., R.A.A., Q.Z., M.K.H., D.Č.), Johns Hopkins University, Baltimore, MD.
Katrina M RodriguezDepartment of Mental Health, Bloomberg School of Public Health (K.M.R.), Johns Hopkins University, Baltimore, MD.ORCID 0000-0001-7044-4588
Monica V TalorDepartment of Pathology, School of Medicine (W.B.-B., T.W., M.V.T., R.A.A., Q.Z., M.K.H., D.Č.), Johns Hopkins University, Baltimore, MD.
Byoung C OhDepartment of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation Laboratory, School of Medicine (B.C.O., G.B.), Johns Hopkins University, Baltimore, MD.
Jan GriffinDivision of Cardiology, Department of Medicine, School of Medicine (N.A.G., J.G., I.W., K.S., S.D.R.), Johns Hopkins University, Baltimore, MD.ORCID 0000-0003-1729-7464
Ilan WittsteinDivision of Cardiology, Department of Medicine, School of Medicine (N.A.G., J.G., I.W., K.S., S.D.R.), Johns Hopkins University, Baltimore, MD.
Kavita SharmaDivision of Cardiology, Department of Medicine, School of Medicine (N.A.G., J.G., I.W., K.S., S.D.R.), Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-3012-1765
John SkinnerDepartment of Anesthesiology and Critical Care Medicine, Division of Adult Anesthesia, School of Medicine (J.S., R.A.J.), Johns Hopkins University, Baltimore, MD.
Roger A JohnsDepartment of Pathology, School of Medicine (W.B.-B., T.W., M.V.T., R.A.A., Q.Z., M.K.H., D.Č.), Johns Hopkins University, Baltimore, MD.
Stuart D RussellDivision of Cardiology, Department of Medicine, School of Medicine (N.A.G., J.G., I.W., K.S., S.D.R.), Johns Hopkins University, Baltimore, MD.
Robert A AndersDepartment of Pathology, School of Medicine (W.B.-B., T.W., M.V.T., R.A.A., Q.Z., M.K.H., D.Č.), Johns Hopkins University, Baltimore, MD.
Qingfeng ZhuDepartment of Pathology, School of Medicine (W.B.-B., T.W., M.V.T., R.A.A., Q.Z., M.K.H., D.Č.), Johns Hopkins University, Baltimore, MD.
Marc K HalushkaDepartment of Pathology, School of Medicine (W.B.-B., T.W., M.V.T., R.A.A., Q.Z., M.K.H., D.Č.), Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-7112-7389
Gerald BrandacherDepartment of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation Laboratory, School of Medicine (B.C.O., G.B.), Johns Hopkins University, Baltimore, MD.ORCID 0000-0001-7790-441X
Daniela ČihákováDepartment of Pathology, School of Medicine (W.B.-B., T.W., M.V.T., R.A.A., Q.Z., M.K.H., D.Č.), Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-8713-2860

Funding

PSYCHIATRIC EPIDEMIOLOGY TRAINING PROGRAMT32MH014592 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HEATHER E VOLK, Peter P. Zandi · 1985 to 2026
$8.5M
Myeloid Cells are Critical in Inflammatory Heart DiseaseR01HL118183 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CIHAKOVA, DANIELA · 2014 to 2023
$4.4M
Fine Dissection of Atherosclerosis Microenvironment RNA ExpressionR01HL137811 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HALUSHKA, MARC K · 2017 to 2020
$2.4M
Role of Sca-1+Cardiac Fibroblasts in Inflammatory Heart Disease`R01HL136586 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CIHAKOVA, DANIELA · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL118183NHLBI NIH HHS R01 HL136586NHLBI NIH HHS R01 HL137811NIMH NIH HHS T32 MH014592
6 · The paper itself

Abstract

backgroundThe role of checkpoint axes in transplantation has been partially addressed in animal models but not in humans. Occurrence of fulminant myocarditis with allorejection-like immunologic features in patients under anti-PD1 (programmed death cell protein 1) treatment suggests a key role of the PD1/PD-L1 (programmed death ligand 1) axis in cardiac immune homeostasis.

methodsWe cross-sectionally studied 23 heart transplant patients undergoing surveillance endomyocardial biopsy. Endomyocardial tissue and peripheral blood mononuclear cells were analyzed by flow cytometry. Multivariate logistic regression analyses including demographic, clinical, and hemodynamic parameters were performed. Murine models were used to evaluate the impact of PD-L1 endothelial graft expression in allorejection.

resultsWe found that myeloid cells dominate the composition of the graft leukocyte compartment in most patients, with variable T-cell frequencies. The CD (cluster of differentiation) 4:CD8 T-cell ratios were between 0 and 1.5. The proportion of PD-L1 expressing cells in graft endothelial cells, fibroblasts, and myeloid leukocytes ranged from negligible up to 60%. We found a significant inverse logarithmic correlation between the proportion of PD-L1

conclusionsLoss of graft endothelial PD-L1 expression may play a role in regulating CD8

Indexed as

Heart TransplantationAdultAnimalsB7-H1 AntigenCD8-Positive T-LymphocytesEndothelial CellsHeart FailureHumansLeukocytes, MononuclearMiceMiddle AgedProgrammed Cell Death 1 ReceptorB7-H1 AntigenCD274 protein, humanProgrammed Cell Death 1 Receptorbiopsyendotheliumfibroblastsflow cytometryheart transplantation

Identifiers

PMID34555935
PMCPMC8550427

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.