ArticleFacts, views & vision in ObGyn2021
The severity and frequency distribution of endometriosis subtypes at different ages: a model to understand the natural history of endometriosis based on single centre/single surgeon data.
Article in Facts, views & vision in ObGyn, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Age-dependent variations in clinical features and operative time for endometriotic cysts.Scientific reports · 2025Article
- Clinical value of preoperative serum calcium level in predicting deep infiltrative endometriosis among ovarian endometrioma.Annals of medicine · 2025Observational
- Understanding Peritoneal Fluid Estrogen and Progesterone Concentrations Permits Individualization of Medical Treatment of Endometriosis-Associated Pain with Lower Doses, Especially in Adolescents Not Requiring Contraception.Journal of clinical medicine · 2025Review
- Laparoscopic hysterectomy for deep infiltrating endometriosis: anterior colpotomy first technique.Facts, views & vision in ObGyn · 2025Article
- Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium.Human reproduction open · 2025Article
- Inflammatory Bowel Disease and Endometriosis: Diagnosis and Clinical Characteristics.Biomedicines · 2024Review
- The anatomy of the pelvic plexus in female cadavers: implications for retroperitoneal nerve-sparing surgery.Facts, views & vision in ObGyn · 2024Article
- Proposal for targeted, neo-evolutionary-oriented, secondary prevention of early-onset endometriosis and adenomyosis. Part I: pathogenic aspects.Human reproduction (Oxford, England) · 2024Article
- Postoperative Reproductive Outcomes in Patients with Endometriosis-Associated Infertility: A Single-Center Retrospective Study.Gynecologic and obstetric investigation · 2024Article
- A Large Ovarian Endometrioma Occupying the Abdominal Cavity in a Postmenopausal Patient: A Case Report.Medicina (Kaunas, Lithuania) · 2023Article
- The 10 "Cardinal Sins" in the Clinical Diagnosis and Treatment of Endometriosis: A Bayesian Approach.Journal of clinical medicine · 2023Article
- Diagnosis and treatment of early-stage endometriosis by Transvaginal Hydro laparoscopy.Facts, views & vision in ObGyn · 2023Article
- Reconsidering evidence-based management of endometriosis.Facts, views & vision in ObGyn · 2022Article
- New Understanding of Diagnosis, Treatment and Prevention of Endometriosis.International journal of environmental research and public health · 2022Review
- Pathogenesis Based Diagnosis and Treatment of Endometriosis.Frontiers in endocrinology · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: to study the natural history of endometriosis. Materials and methods: the analysis of all women (n=2086) undergoing laparoscopy for pelvic pain and endometriosis between 1988 and 2011 at University Hospital Gasthuisberg. Main outcome measures: the severity of subtle, typical, cystic and deep endometriosis in adult women, with or without a pregnancy, as estimated by their pelvic area and their volume. Results: the number of women undergoing a laparoscopy increased up to 28 years of age and decreased thereafter. Between 24 and 44 years, the severity and relative frequencies of subtle, typical, cystic and deep lesions did not vary significantly. The number of women younger than 20 years was too small to ascertain the impression of less severe lesions. The severity of endometriosis lesions was not less in women with 1 or more previous pregnancies or with previous surgery. There was no bias over time since the type and severity of endometriosis lesions remained constant between 1988 and 2011. Conclusions: severity of endometriosis does not increase between 24 and 44 years of age, suggesting that growth is limited by intrinsic or extrinsic factors. Severity was not lower in women with a previous pregnancy. What is new: considering the time needed for lesions to become symptomatic together with the diagnostic delay, the decreasing number of laparoscopies after age 28 is compatible with a progressively declining risk of initiating endometriosis lesions after menarche, the remaining women being progessively less susceptible.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.