Evidence map›Paper›PMID 34555840›Full record

ArticleNature2021

Architecture and assembly mechanism of native glycine receptors.

Hongtao Zhu, Eric Gouaux

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 87 citations in OpenAlex.

  1. Review
  2. Review
  3. When can AlphaFold predict the oligomeric states of proteins?Protein science : a publication of the Protein Society · 2026
    Article
  4. Human GlyRα2 pore dynamics in gating and inhibition.Structure (London, England : 1993) · 2026
    Article
  5. Article
  6. Efficient and rapid isolation of native AMPA receptor complexes for cryo-EM.Protein science : a publication of the Protein Society · 2026
    Article
  7. Article
  8. Article
  9. Excitatory glycine receptors control ventral hippocampus synaptic plasticity and anxiety-related behaviors.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Dynamics and Interplay of the Binding Pockets in the Glycine Receptor.Journal of chemical information and modeling · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Hongtao ZhuVollum Institute, Oregon Health and Science University, Portland, OR, USA.
Eric GouauxVollum Institute, Oregon Health and Science University, Portland, OR, USA. gouauxe@ohsu.edu.ORCID http://orcid.org/0000-0002-8549-2360
Howard Hughes Medical Institute · USOregon Health & Science University · US

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Structural biology of neurotransmitter ion channelsR01GM100400 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI GOUAUX, JAMES E · 2012 to 2020
$2.3M
NIGMS NIH HHS R01 GM100400NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

Glycine receptors (GlyRs) are pentameric, 'Cys-loop' receptors that form chloride-permeable channels and mediate fast inhibitory signalling throughout the central nervous system

Indexed as

Cryoelectron MicroscopyAnimalsBrain StemModels, MolecularPhenylalaninePicrotoxinProtein SubunitsReceptors, GlycineSpinal CordSwinePhenylalaninePicrotoxinProtein SubunitsReceptors, Glycine

Identifiers

PMID34555840
PMCPMC8647860
OpenAlexW3199831722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.