Evidence map›Paper›PMID 34555812›Full record

ArticleAging2021

High CTSL2 expression predicts poor prognosis in patients with lung adenocarcinoma.

Junnian Song, Jindong Jiang, Na Wei, Zongsheng Duan, Gang Wang, Weiyun Pan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Junnian SongDepartment of First Operating Room, The First Hospital of Jilin University, Changchun 130021, China.
Jindong JiangDepartment of Thoracic Surgery, The First Hospital of Jilin University, Changchun 130021, China.
Na WeiDepartment of First Operating Room, The First Hospital of Jilin University, Changchun 130021, China.
Zongsheng DuanDepartment of Anesthesiology, The First Hospital of Jilin University, Changchun 130021, China.
Gang WangDepartment of Second Operating Room, The First Hospital of Jilin University, Changchun 130021, China.
Weiyun PanDepartment of Intensive Care Unit, The First Hospital of Jilin University, Changchun 130021, China.
First Hospital of Jilin University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cathepsin like 2 (CTSL2) is a lysosomal cysteine protease, and may be associated with tumor metastasis. However, CTSL2 has not been reported as a biomarker in lung adenocarcinoma (LUAD). In this study, bioinformatics analysis using data from The Cancer Genome Atlas was performed. Wilcoxon rank-sum test and chi-square test were carried out. Kaplan-Meier and Cox regression were performed to evaluate the effect of CTSL2 expression in the overall survival. Our results indicated that CTSL2 in tumor was significantly higher than that in normal tissue (

Indexed as

PrognosisA549 CellsAdenocarcinoma of LungAgedAge FactorsComputational BiologyCysteine ProteasesDatasets as TopicFemaleHumansLung NeoplasmsMaleMiddle AgedRisk FactorsCysteine ProteasesCTSL2gene set enrichment analysislung adenocarcinomanomogramprognostic biomarker

Identifiers

PMID34555812
PMCPMC8507295
OpenAlexW3199058613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.