ArticleDevelopmental cognitive neuroscience2021
Identifying profiles of brain structure and associations with current and future psychopathology in youth.
Article in Developmental cognitive neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Multisystem Environmental Factors Elucidate Shared and Distinct Associations With Brain and Behavior in Adolescents.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Interrogating cognitive and neural group variation in childhood: Examples in adolescent brain cognitive development and Oregon attention-deficit/hyperactivity disorder-1000 cohorts.Journal of psychopathology and clinical science · 2026Article
- Distinct associations between multimodal brain measures and psychopathology domains predict adolescent functioning.bioRxiv : the preprint server for biology · 2026Article
- Article
- Individual Differences in Developmental Trajectories of Global and Subcortical Brain Volumes Between Late Childhood and Late Adolescence: Findings From a 12-Wave Neuroimaging Study.Human brain mapping · 2025Article
- Latent Profiles of Childhood Adversity, Adolescent Mental Health, and Neural Network Connectivity.JAMA network open · 2024Article
- The Cerebellum and Cognitive Function: Anatomical Evidence from a Transdiagnostic Sample.Cerebellum (London, England) · 2024Article
- Everyday home radon exposure is associated with altered structural brain morphology in youths.Neurotoxicology · 2024Article
- Adolescent brain cognitive development study: Longitudinal methods, developmental findings, and associations with environmental risk factors.Developmental cognitive neuroscience · 2023Article
- Developmental brain changes during puberty and associations with mental health problems.Developmental cognitive neuroscience · 2023Article
- Neuroimaging brain growth charts: A road to mental health.Psychoradiology · 2021Article
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Authors and funding
3 authors.
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Abstract
Brain structure is often studied as a marker of youth psychopathology by examining associations between volume or thickness of individual regions and specific diagnoses. However, these univariate approaches do not address whether the effect of a particular region may depend on the structure of other regions. Here, we identified subgroups of individuals with distinct profiles of brain structure and examined how these profiles were associated with concurrent and future youth psychopathology. We used latent profile analysis to identify distinct neuroanatomical profiles of subcortical region volume and orbitofrontal cortical thickness in the ABCD study (N = 9376, mean age = 9.91, SD = 0.62). We identified a five-profile solution consisting of a reduced subcortical volume profile, a reduced orbitofrontal thickness profile, a reduced limbic and elevated striatal volume profile, an elevated orbitofrontal thickness and reduced striatal volume profile, and an elevated orbitofrontal thickness and subcortical volume profile. While controlling for age, sex, and intracranial volume, profiles exhibited differences in concurrent psychopathology measured dimensionally and categorically and in psychopathology at 1-year follow-up measured dimensionally. Results show that profiles of brain structure have incremental validity for associations with youth psychopathology beyond intracranial volume.
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