Evidence map›Paper›PMID 34555560›Full record

ArticleAddictive behaviors2022

E-cigarette device and liquid characteristics and E-cigarette dependence: A pilot study of pod-based and disposable E-cigarette users.

Elizabeth K Do, Katie O'Connor, Siobhan N Perks, Eric K Soule, Thomas Eissenberg, Michael S Amato, Amanda L Graham, Corby K Martin, Christoph Höchsmann, Bernard F Fuemmeler

Open access · greenAbstract read
In one paragraph

Article in Addictive behaviors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. What is the Addictive Potential from Vaping?Nordisk alkohol- & narkotikatidskrift : NAT · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Nicotine Intake in Adult Pod E-cigarette Users: Impact of User and Device Characteristics.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023
    Article
  13. Trends in Nicotine Strength in Electronic Cigarettes Sold in the United States by Flavor, Product Type, and Manufacturer, 2017-2022.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Elizabeth K DoSchroeder Institute at Truth Initiative, Washington, DC, USA; Department of Health Behavior and Policy, Virginia Commonwealth University, USA; Department of Epidemiology, Milken Institute of Public Health, The George Washington University, Washington, DC, USA. Electronic address: edo@truthinitiative.org.
Katie O'ConnorSchroeder Institute at Truth Initiative, Washington, DC, USA. Electronic address: koconnor@truthinitiative.org.
Siobhan N PerksSchroeder Institute at Truth Initiative, Washington, DC, USA. Electronic address: sperks@truthinitiative.org.
Eric K SouleDepartment of Health Education and Promotion, Milken Institute School of Public Health, East Carolina University, Greenville, NC, USA; Center for the Study of Tobacco Products, Psychology Department (Health Program), Virginia Commonwealth University, Richmond, VA, USA. Electronic address: soulee18@ecu.edu.
Thomas EissenbergCenter for the Study of Tobacco Products, Psychology Department (Health Program), Virginia Commonwealth University, Richmond, VA, USA. Electronic address: teissenb@vcu.edu.
Michael S AmatoTruth Initiative Innovations Department, Washington, DC, USA; Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. Electronic address: mamato@truthinitiative.org.
Amanda L GrahamTruth Initiative Innovations Department, Washington, DC, USA; Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. Electronic address: agraham@truthinitiative.org.
Corby K MartinPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA. Electronic address: Corby.Martin@pbrc.edu.
Christoph HöchsmannPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA. Electronic address: Christoph.Hoechsmann@pbrc.edu.
Bernard F FuemmelerDepartment of Health Behavior and Policy, Virginia Commonwealth University, USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: Bernard.Fuemmeler@vcuhealth.org.
American Legacy Foundation · USPennington Biomedical Research Center · USVirginia Commonwealth University · USMilken Institute · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Project 4: Using a prospective cohort survey to test population-level predictions generated by Projects 1-3U54DA036105 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BRELAND, ALISON · 2018 to 2022
$20.8M
SmartVape: Real-time assessment of ECIG device characteristics using a smartphone app.R21CA239188 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI EISSENBERG, THOMAS EVAN, FUEMMELER, BERNARD F · 2019 to 2020
$434k
NCI NIH HHS R21 CA239188NIDA NIH HHS U54 DA036105NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

backgroundE-cigarette device and liquid characteristics, such as electrical power output and liquid nicotine concentration, determine the rate at which nicotine is emitted from the e-cigarette (i.e., nicotine flux), and thus are likely to influence user nicotine dependence. We hypothesize that nicotine flux would be associated with the E-cigarette Dependence Scale (EDS) among pod-based and disposable e-cigarette products.

methodsData were obtained from online panel participants between 18 and 65 years of age, who had indicated that they were either former or current e-cigarette users and resided within the United States (N = 1036). To be included in these analyses, participants had to provide information regarding device type (pod-based or disposable), power (watts), and nicotine concentration (mg/mL), from which we could determine nicotine flux (µg/s) (N = 666). To assess the relationship between nicotine flux and EDS, a series of multivariable linear regressions were conducted. Each model was separated by device type and adjusted for by age and past 30-day e-cigarette use.

resultsGreater nicotine flux was associated with higher EDS scores among pod-based e-cigarette users (beta = 0.19, SE = 0.09, p-value = 0.043), but not users of disposable e-cigarettes. Neither power nor nicotine concentration were associated with EDS scores among users of either e-cigarette device type.

conclusionResults support the hypothesis that nicotine flux is positively associated with nicotine dependence in a sample of current users of pod-based and disposable e-cigarettes.

Indexed as

Electronic Nicotine Delivery SystemsTobacco ProductsTobacco Use DisorderVapingHumansPilot ProjectsUnited StatesE-cigaretteNicotine concentrationNicotine dependenceNicotine fluxPower

Identifiers

PMID34555560
PMCPMC8511126
OpenAlexW3201348536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.