Evidence map›Paper›PMID 34555557›Full record

ArticleJournal of electrocardiology

Premature atrial stimulation accentuates conduction abnormalities in cardiac surgery patients that develop postoperative atrial fibrillation.

Muhammad S Khan, Matthias Lange, Ravi Ranjan, Vikas Sharma, Jason P Glotzbach, Craig Selzman, Derek J Dosdall

Open access · greenAbstract read
In one paragraph

Article in Journal of electrocardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Premature atrial contractions promote local directional heterogeneities in conduction velocity vectors.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  2. DefiPaceReviews in cardiovascular medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Muhammad S KhanNora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah - Health, Salt Lake City, UT 84112, USA.
Matthias LangeNora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah - Health, Salt Lake City, UT 84112, USA.
Ravi RanjanNora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah - Health, Salt Lake City, UT 84112, USA; Division of Cardiovascular Medicine, Department of Internal Medicine, The University of Utah - Health, Salt Lake City, UT 84112, USA; Department of Bioengineering, The University of Utah - Health, Salt Lake City, UT 84112, USA.
Vikas SharmaDivision of Cardiothoracic Surgery, Department of Surgery, The University of Utah - Health, Salt Lake City, UT 84112, USA.
Jason P GlotzbachDivision of Cardiothoracic Surgery, Department of Surgery, The University of Utah - Health, Salt Lake City, UT 84112, USA.
Craig SelzmanNora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah - Health, Salt Lake City, UT 84112, USA; Division of Cardiothoracic Surgery, Department of Surgery, The University of Utah - Health, Salt Lake City, UT 84112, USA.
Derek J DosdallNora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah - Health, Salt Lake City, UT 84112, USA; Division of Cardiovascular Medicine, Department of Internal Medicine, The University of Utah - Health, Salt Lake City, UT 84112, USA; Department of Bioengineering, The University of Utah - Health, Salt Lake City, UT 84112, USA; Division of Cardiothoracic Surgery, Department of Surgery, The University of Utah - Health, Salt Lake City, UT 84112, USA. Electronic address: derek.dosdall@utah.edu.
University of Utah · US

Funding

TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
His-Purkinje Pacing for Low Energy Implantable Cardioverter DefibrillatorsR01HL128752 · NHLBI · UNIVERSITY OF UTAH · PI DOSDALL, DEREK J · 2015 to 2024
$5.0M
Myocardial Substrate Driven Mechanistic Insights into Atrial FibrillationR01HL142913 · NHLBI · UNIVERSITY OF UTAH · PI RANJAN, RAVI · 2018 to 2021
$2.4M
Unlocking Trafficking Specificity for Cx43 Gap JunctionsR01HL152691 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Robin M Shaw · 2020 to 2026
$2.0M
Novel lead for selective His bundle sensing and low-threshold pacingR21HL156039 · NHLBI · UNIVERSITY OF UTAH · PI DOSDALL, DEREK J · 2021 to 2022
$419k
NHLBI NIH HHS R01 HL128752NHLBI NIH HHS R01 HL142913NHLBI NIH HHS R01 HL152691NHLBI NIH HHS R21 HL156039NHLBI NIH HHS T32 HL007576
6 · The paper itself

Abstract

backgroundpostoperative atrial fibrillation (POAF) is a common cardiac surgery complication that is associated with increased complications and negative outcomes, but the association between presurgical atrial conduction abnormalities and POAF has not been investigated clinically during premature atrial S1S2 stimulation. This clinical study sought to examine whether intraoperative premature atrial stimulation reveals increased areas of slowed and/or blocked conduction in patients that develop POAF.

methodsHigh-density intraoperative epicardial left atrial mapping was conducted in 20 cardiac surgery patients with no prior history of atrial fibrillation (AF). In 20 patients, 6 (30%) developed POAF. A flexible-array of 240-electrodes was placed on the posterior left atrial wall in between the pulmonary veins. Activation maps were generated for sinus and premature atrial S1S2 stimulated beats. The area of conduction block (CB), conduction delay (CD) and the combination of both (CDCB) for conduction velocity < 0.1, 0.1 ≤ x < 0.2 and < 0.2 m/s, respectively were quantified.

resultsFor a premature atrial S2 beat with shortest cycle length captured, conduction velocity maps revealed a significantly higher area for CD (13.19 ± 6.59 versus 6.06 ± 4.22 mm

conclusionIn comparison to sinus and S1 beats, premature atrial S2 beats accentuate conduction abnormalities in the posterior left atrial wall of cardiac surgery patients that developed POAF.

Indexed as

Atrial FibrillationCardiac Surgical ProceduresElectrocardiographyHeart AtriaHumansPostoperative ComplicationsConduction disordersElectrical mappingpacingPostoperative atrial fibrillationPremature atrial stimulation

Identifiers

PMID34555557
PMCPMC9265137
OpenAlexW3200384838

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.