Evidence map›Paper›PMID 34555516›Full record

ArticleContemporary clinical trials2021

Evaluating the efficacy of mindfulness and acceptance-based treatment components for weight loss: Protocol for a multiphase optimization strategy trial.

Evan M Forman, Christina Chwyl, Michael P Berry, Lauren C Taylor, Meghan L Butryn, Donna L Coffman, Adrienne Juarascio, Stephanie M Manasse

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in Contemporary clinical trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06292936 (Evaluation of a Remotely-Delivered Behavioral Intervention for Post-Bariatric Surgery Weight Regain), which is not on this map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06292936 narecruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation of a Remotely-Delivered Behavioral Intervention for Post-Bariatric Surgery Weight Regain

TypeinterventionalSponsorTemple UniversityRan2024 to 2028Enrolled200ConditionsObesity, Bariatric Surgery CandidateArmsAcceptance-Based Behavioral Intervention
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Racial disparities in the efficacy of traditional versus acceptance-based behavioral weight loss.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
    Trial
  6. Trial
  7. Trial
  8. Moderators of the relation between physical activity and subsequent energy intake among behavioral weight loss participants.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
    Article
  9. Article
  10. Acceptance and Commitment Therapy for Obesity.Current obesity reports · 2025
    Review
  11. Intraday relations between physical activity and energy intake among behavioral weight loss participants.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Evan M FormanCenter for Weight, Eating, and Lifestyle Sciences (WELL Center), Drexel University, Philadelphia, PA, USA. Electronic address: emf27@drexel.edu.
Christina ChwylCenter for Weight, Eating, and Lifestyle Sciences (WELL Center), Drexel University, Philadelphia, PA, USA.
Michael P BerryCenter for Weight, Eating, and Lifestyle Sciences (WELL Center), Drexel University, Philadelphia, PA, USA.
Lauren C TaylorCenter for Weight, Eating, and Lifestyle Sciences (WELL Center), Drexel University, Philadelphia, PA, USA.
Meghan L ButrynCenter for Weight, Eating, and Lifestyle Sciences (WELL Center), Drexel University, Philadelphia, PA, USA.
Donna L CoffmanCollege of Public Health, Temple University, Philadelphia, PA, USA.
Adrienne JuarascioCenter for Weight, Eating, and Lifestyle Sciences (WELL Center), Drexel University, Philadelphia, PA, USA.
Stephanie M ManasseCenter for Weight, Eating, and Lifestyle Sciences (WELL Center), Drexel University, Philadelphia, PA, USA.

Funding

New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
Mindfulness and acceptance-based interventions for obesity: Using a factorial design to identify the most effective componentsR01DK119658 · NIDDK · DREXEL UNIVERSITY · PI ZHANG, FENGQING · 2019 to 2023
$3.0M
NIDDK NIH HHS P30 DK111022NIDDK NIH HHS R01 DK119658
6 · The paper itself

Abstract

Behavioral weight loss treatment (BT) for individuals with overweight and obesity is effective but leaves room for improvement. Mindfulness and acceptance-based treatments may bolster weight loss outcomes; yet, little is known about the efficacy of the individual components or the combinations of components that are most effective in producing weight loss above and beyond standard BT strategies for weight loss. This protocol manuscript describes the use of a multiphase optimization strategy to evaluate the independent and combinatory efficacy of three mindfulness and acceptance-based components (mindful awareness, willingness, values). Using a 2 × 2 × 2 factorial design, participants (N = 288) will be randomized to one of eight conditions, each representing a combination of core MABT strategies in addition to foundational BT strategies. Assessments occur at baseline, mid-treatment (week 24 through 26), post-treatment, and at 6, 12, and 24-month follow-up. The primary aim is to elucidate the independent efficacy of each MABT component on weight loss above gold-standard BT. The secondary aims are to evaluate the independent effect of these components on calorie intake, physical activity, and overall quality of life; evaluate target engagement (i.e., the degree to which each treatment component affects proposed mechanisms of action); and evaluate the potential moderating effect of susceptibility to internal and external food cues on outcomes. The exploratory aim is to quantify any component interaction effects (which may be synergistic, fully additive, or partially additive).

Indexed as

MindfulnessWeight LossHumansObesityOverweightQuality of LifeTreatment OutcomeAcceptance and commitment therapyMultiphase optimization strategyObesityOverweightWeight control

Identifiers

PMID34555516
PMCPMC8722456

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.