Evidence map›Paper›PMID 34555289›Full record

ReviewAnnual review of pharmacology and toxicology2022

E-Cigarette Toxicology.

Terry Gordon, Emma Karey, Meghan E Rebuli, Yael-Natalie H Escobar, Ilona Jaspers, Lung Chi Chen

Abstract readReview
In one paragraph

Review in Annual review of pharmacology and toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The Effect of Nicotine-Containing Products on Peri-Implant Tissues: A Systematic Review and Network Meta-Analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024
    Pooled it
  2. Pooled it
  3. ACT on Vaping: Pilot Randomized Controlled Trial of a Novel Digital Health App With Text Messaging for Young Adult Vaping Cessation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Vaping-related lung disease: a narrative review.Journal of thoracic disease · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. 7-OH and kratom vaping products: an emerging public health threat.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  18. Article
  19. Influence of e-cigarettes and their constituents on cardiac rhythm and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  20. Review

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Terry GordonDepartment of Environmental Medicine, NYU School of Medicine, New York, NY 10010, USA; email: terry.gordon@nyumc.org.
Emma KareyDepartment of Environmental Medicine, NYU School of Medicine, New York, NY 10010, USA; email: terry.gordon@nyumc.org.
Meghan E RebuliDepartment of Pediatrics and Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA.
Yael-Natalie H EscobarCurriculum in Toxicology and Environmental Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA.
Ilona JaspersDepartment of Pediatrics and Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA.
Lung Chi ChenDepartment of Environmental Medicine, NYU School of Medicine, New York, NY 10010, USA; email: terry.gordon@nyumc.org.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELIKOFF, JUDITH TERRY · 1985 to 2020
$26.1M
TOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0M
TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007324 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CUDDAPAH, SURESH · 1999 to 2025
$5.8M
E-cig flavors and their effects on respiratory innate immune responsesR01HL139369 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA · 2017 to 2020
$2.4M
Air Quality, Child, and Adult Health in Homes Where E-Cigarettes Are SmokedR01HL139239 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORDON, TERRY, WEITZMAN, MICHAEL LANE · 2017 to 2020
$2.0M
The adverse chronic effects of e-cigarettes: puff profiles, sex, genetics, and flavorings as modifying factorsR01CA239253 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORDON, TERRY · 2018 to 2022
$1.5M
NCI NIH HHS R01 CA239253NHLBI NIH HHS R01 HL139239NHLBI NIH HHS R01 HL139369NIEHS NIH HHS P30 ES000260NIEHS NIH HHS P30 ES010126NIEHS NIH HHS T32 ES007126NIEHS NIH HHS T32 ES007324
6 · The paper itself

Abstract

Since the spread of tobacco from the Americas hundreds of years ago, tobacco cigarettes and, more recently, alternative tobacco products have become global products of nicotine addiction. Within the evolving alternative tobacco product space, electronic cigarette (e-cigarette) vaping has surpassed conventional cigarette smoking among adolescents and young adults in the United States and beyond. This review describes the experimental and clinical evidence of e-cigarette toxicity and deleterious health effects. Adverse health effects related to e-cigarette aerosols are influenced by several factors, including e-liquid components, physical device factors, chemical changes related to heating, and health of the e-cigarette user (e.g., asthmatic). Federal, state, and local regulations have attempted to govern e-cigarette flavors, manufacturing, distribution, and availability, particularly to underaged youths. However, the evolving e-cigarette landscape continues to impede timely toxicological studies and hinder progress made toward our understanding of the long-term health consequence of e-cigarettes.

Indexed as

Electronic Nicotine Delivery SystemsTobacco ProductsVapingAdolescentHumansUnited StatesYoung Adultcardiovascularelectronic cigarettesrespiratorytoxicologyvaping

Identifiers

PMID34555289
PMCPMC9386787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.