Evidence map›Paper›PMID 34555264›Full record

ReviewInternational journal of immunogenetics2022

BSHI/BTS guidance on crossmatching before deceased donor kidney transplantation.

S Peacock, D Briggs, M Barnardo, R Battle, P Brookes, C Callaghan, B Clark, C Collins, S Day, N Diaz Burlinson and 20 more

Abstract readReview
In one paragraph

Review in International journal of immunogenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

S PeacockTissue Typing Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.ORCID https://orcid.org/0000-0002-4414-8432
D BriggsH&I Laboratory, NHSBT Birmingham Vincent Drive, Birmingham, UK.ORCID https://orcid.org/0000-0002-6796-7086
M BarnardoClinical Transplant Immunology, Churchill Hospital, Oxford, UK.
R BattleH&I Laboratory, SNBTS, Edinburgh, UK.
P BrookesH&I Laboratory, Harefield Hospital, Harefield, UK.
C CallaghanDepartment of Nephrology and Transplantation, Guy's Hospital, London, UK.
B ClarkH&I Laboratory, Leeds Teaching Hospitals NHS Trust, UK.ORCID https://orcid.org/0000-0001-7243-1916
C CollinsH&I Laboratory, NHSBT Birmingham Vincent Drive, Birmingham, UK.
S DayH&I Laboratory, Southmead Hospital, Bristol, UK.
N Diaz BurlinsonTransplantation Laboratory, Manchester Royal Infirmary, Manchester, UK.
P DunnTransplant Laboratory, Leicester General Hospital, Leicester, UK.
R FernandoH&I Laboratory, The Anthony Nolan Laboratories, Royal Free Hospital, UK.
S FuggleOrgan Donation & Transplantation, NHSBT, Stoke Gifford, Bristol, UK.
A HarmerH&I Laboratory, NHSBT Barnsley Centre, Barnsley, UK.
D KallonH & I Laboratory, Royal London Hospital, London, UK.
D KeeganDepartment of H&I, Beaumont Hospital, Dublin, UK.
T KeyH&I Laboratory, NHSBT Barnsley Centre, Barnsley, UK.
E LawsonOrgan Donation and Transplantation, NHSBT, Birmingham, UK.
S LloydWelsh Transplantation & Immunogenetics Laboratory, Cardiff, UK.
J MartinH&I Laboratory, Belfast Health and Social Care Trust, Belfast, UK.
J McCaughanH&I Laboratory, Belfast Health and Social Care Trust, Belfast, UK.
D MiddletonH&I Laboratory, Liverpool Foundation Trust, Liverpool, UK.ORCID https://orcid.org/0000-0002-6688-8642
F PartheniouH&I Laboratory, Liverpool Foundation Trust, Liverpool, UK.
A PolesH&I Laboratory, University Hospitals Plymouth, Plymouth, UK.
T ReesWelsh Transplantation & Immunogenetics Laboratory, Cardiff, UK.
D SageH&I Laboratory, NHSBT Tooting Centre, London, UK.
E Santos-NunezH&I Laboratory, Imperial College Healthcare NHS Trust, London, UK.
O ShawH&I Laboratory, Viapath, Guys & St Thomas, London, UK.
M WillicombeDepartment of Immunology and Inflammation, Imperial College London, UK.
J WorthingtonTransplantation Laboratory, Manchester Royal Infirmary, Manchester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

All UK H&I laboratories and transplant units operate under a single national kidney offering policy, but there have been variations in approach regarding when to undertake the pre-transplant crossmatch test. In order to minimize cold ischaemia times for deceased donor kidney transplantation we sought to find ways to be able to report a crossmatch result as early as possible in the donation process. A panel of experts in transplant surgery, nephrology, specialist nursing in organ donation and H&I (all relevant UK laboratories represented) assessed evidence and opinion concerning five factors that relate to the effectiveness of the crossmatch process, as follows: when the result should be ready for reporting; what level of donor HLA typing is needed; crossmatch sample type and availability; fairness and equity; risks and patient safety. Guidelines aimed at improving practice based on these issues are presented, and we expect that following these will allow H&I laboratories to contribute to reducing CIT in deceased donor kidney transplantation.

Indexed as

Kidney TransplantationBlood Grouping and CrossmatchingCold IschemiaHistocompatibility TestingHLA AntigensHumansKidneyHLA AntigensantibodiesHLAkidney transplantationvirtual crossmatching

Identifiers

PMID34555264
PMCPMC9292213

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.