Evidence map›Paper›PMID 34555263›Full record

Trial reportBJOG : an international journal of obstetrics and gynaecology2022

Association of hysterectomy and invasive epithelial ovarian and tubal cancer: a cohort study within UKCTOCS.

J A Taylor, M Burnell, A Ryan, C Karpinskyj, J K Kalsi, H Taylor, S Apostolidou, A Sharma, R Manchanda, R Woolas and 6 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BJOG : an international journal of obstetrics and gynaecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

J A TaylorMRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.ORCID 0000-0002-7698-6991
M BurnellMRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.
A RyanMRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.
C KarpinskyjMRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.
J K KalsiDepartment of Women's Cancer, Institute for Women's Health, University College London, London, UK.
H TaylorDepartment of Surgery and Cancer, Imperial College Healthcare NHS Trust, London, UK.
S ApostolidouMRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.
A SharmaDepartment of Obstetrics and Gynaecology, University Hospital of Wales, Cardiff, UK.
R ManchandaBarts Health NHS Trust and Wolfson Institute of Preventive Medicine, CRUK Barts Cancer Centre, Queen Mary University of London, London, UK.ORCID 0000-0003-3381-5057
R WoolasDepartment of Gynaecological Oncology, Queen Alexandra Hospital, Portsmouth, UK.
S CampbellCreate Fertility, London, UK.
M ParmarMRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.ORCID 0000-0003-0166-1700
N SinghDepartment of Cellular Pathology, Barts Health NHS Trust, London, UK.
I J JacobsDepartment of Women's Cancer, Institute for Women's Health, University College London, London, UK.ORCID 0000-0002-5005-2672
U MenonMRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.ORCID 0000-0003-3708-1732
A Gentry-MaharajMRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.ORCID 0000-0001-7270-9762

Funding

Cancer Research UKHealth Technology Assessment Programme 16/46/01The Eve Appeal
6 · The paper itself

Abstract

objectiveTo investigate the association between hysterectomy with conservation of one or both adnexa and ovarian and tubal cancer.

designProspective cohort study.

settingThirteen NHS Trusts in England, Wales and Northern Ireland. POPULATION: A total of 202 506 postmenopausal women recruited between 2001 and 2005 to the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) and followed up until 31 December 2014.

methodsMultiple sources (questionnaires, hospital notes, Hospital Episodes Statistics, national cancer/death registries, ultrasound reports) were used to obtain accurate data on hysterectomy (with conservation of one or both adnexa) and outcomes censored at bilateral oophorectomy, death, ovarian/tubal cancer diagnosis, loss to follow up or 31 December 2014. Cox proportional hazards regression models were used to assess the association.

main outcome measuresInvasive epithelial ovarian and tubal cancer (WHO 2014) on independent outcome review.

resultsHysterectomy with conservation of one or both adnexa was reported in 41 912 (20.7%; 41 912/202 506) women. Median follow up was 11.1 years (interquartile range 9.96-12.04), totalling >2.17 million woman-years. Among women who had undergone hysterectomy, 0.55% (231/41 912) were diagnosed with ovarian/tubal cancer, compared with 0.59% (945/160 594) of those with intact uterus. Multivariable analysis showed no evidence of an association between hysterectomy and invasive epithelial ovarian/tubal cancer (hazard ratio 0.98, 95% CI 0.85-1.13, P = 0.765).

conclusionsThis large cohort study provides further independent validation that hysterectomy is not associated with alteration of invasive epithelial ovarian and tubal cancer risk. These data are important both for clinical counselling and for refining risk prediction models. TWEETABLE ABSTRACT: Hysterectomy does not alter risk of invasive epithelial ovarian and tubal cancer.

Indexed as

AgedCarcinoma, Ovarian EpithelialCohort StudiesEnglandFallopian Tube NeoplasmsFemaleHumansHysterectomyMiddle AgedNorthern IrelandOvarian NeoplasmsProspective StudiesRisk FactorsState MedicineSurveys and QuestionnairesWalesHysterectomyovarian cancerovarian neoplasmrisktypeUKCTOCS

Identifiers

PMID34555263
PMCPMC7615389

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.