Evidence map›Paper›PMID 34555226›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Phosphodiesterase 4 mediates interleukin-8-induced heterologous desensitization of the β

Thomas C Rich, Silas J Leavesley, Angela P Brandon, Cilina A Evans, S Vamsee Raju, Brant M Wagener

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Thomas C RichDepartment of Pharmacology, University of South Alabama, Mobile, Alabama, USA.
Silas J LeavesleyDepartment of Pharmacology, University of South Alabama, Mobile, Alabama, USA.
Angela P BrandonDivision of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Cilina A EvansDivision of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
S Vamsee RajuDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Brant M WagenerDivision of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0001-7889-1526
University of Alabama at Birmingham · USUniversity of South Alabama · US

Funding

T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F. · 2001 to 2022
$34.6M
The Role of Sex Dimorphism in Post-TBI Bacterial PneumoniaR01GM127584 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WAGENER, BRANT M · 2018 to 2022
$1.9M
Acquired CFTR Dysfunction in Alcohol-related Lung PathologyR01AA027528 · NIAAA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RAJU, S.VAMSEE · 2020 to 2024
$1.9M
NHLBI NIH HHS P01 HL066299NIAAA NIH HHS R01 AA027528NIGMS NIH HHS R01 GM127584
6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) is a life-threatening illness characterized by decreased alveolar-capillary barrier function, pulmonary edema consisting of proteinaceous fluid, and inhibition of net alveolar fluid transport responsible for resolution of pulmonary edema. There is currently no pharmacotherapy that has proven useful to prevent or treat ARDS, and two trials using beta-agonist therapy to treat ARDS demonstrated no effect. Prior studies indicated that IL-8-induced heterologous desensitization of the beta2-adrenergic receptor (β

Indexed as

Animalsbeta-Arrestin 1Bronchoalveolar Lavage FluidCell MembraneChemokine CXCL1Cyclic AMPCyclic Nucleotide Phosphodiesterases, Type 4Down-RegulationInterleukin-8MaleMicePhosphatidylinositol 3-KinasePhosphodiesterase 4 InhibitorsReceptors, Adrenergic, beta-2ADRB2 protein, mousebeta-Arrestin 1Chemokine CXCL1Cxcl1 protein, mouseCyclic AMPCyclic Nucleotide Phosphodiesterases, Type 4Interleukin-8Phosphatidylinositol 3-KinasePhosphodiesterase 4 InhibitorsReceptors, Adrenergic, beta-2acute lung injuryFRETinternalizationrecyclingtrauma

Identifiers

PMID34555226
PMCPMC8483573
OpenAlexW3199755647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.