Evidence map›Paper›PMID 34555162›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022

Sex Differences in Recovery Across Multiple Domains Among Older Adults With Hip Fracture.

Denise L Orwig, Danielle S Abraham, Marc C Hochberg, Ann Gruber-Baldini, Jack M Guralnik, Anne R Cappola, Justine Golden, Gregory E Hicks, Ram R Miller, Barbara Resnick and 4 more

Open access · greenAbstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
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  6. Recovery capital: a concept analysis.Frontiers in public health · 2026
    Review
  7. Review
  8. Association Between Prehip Fracture Antidepressant Use and Posthip Fracture Length of Hospital Stay in Medicare Beneficiaries and Assessing Sex Differences.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025
    Article
  9. Sex-specific associations of vitamin D and bone biomarkers with bone density and physical function during recovery from hip fracture: the Baltimore Hip Studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Denise L OrwigDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA.
Danielle S AbrahamDepartment of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA.
Marc C HochbergDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA.
Ann Gruber-BaldiniDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA.ORCID 0000-0002-0190-1973
Jack M GuralnikDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA.
Anne R CappolaDepartment of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA.
Justine GoldenDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA.
Gregory E HicksDepartment of Physical Therapy, University of Delaware, Newark, USA.
Ram R MillerNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.ORCID 0000-0002-2481-2834
Barbara ResnickDepartment of Organizational Systems and Adult Health, University of Maryland School of Nursing, Baltimore, USA.ORCID 0000-0002-2839-5783
Michelle ShardellDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA.ORCID 0000-0002-5283-2082
Robert S SterlingDepartment of Orthopedics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rashmita BajracharyaDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA.
Jay MagazinerDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA.
University of Maryland, Baltimore · USUniversity of Pennsylvania · USJohns Hopkins University · USNovartis (United States) · USUniversity of Delaware · US

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Sequelae of Hip Fracture in Men: An Epidemiologic StudyR37AG009901 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY · 1992 to 2018
$11.3M
RESEARCH TRAINING IN THE EPIDEMIOLOGY OF AGINGT32AG000262 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ANN L GRUBER-BALDINI, DENISE L ORWIG · 1998 to 2026
$8.2M
The Epidemiology of Bone Strength and Muscle Composition After Hip Fracture in MeR01AG029315 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY · 2007 to 2011
$4.1M
Midcareer Investigator Award in Patient-Oriented Research in AgingK24AG042765 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CAPPOLA, ANNE R · 2013 to 2024
$1.7M
DETERMINANTS OF RECOVERY FROM HIP FX/SUP BONE/MUSCLER55AG009901 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY STEVEN · 1991 to 1991
–
NIA NIH HHS K24 AG042765NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG029315NIA NIH HHS R37 AG009901NIA NIH HHS R37 AG09901NIA NIH HHS T32 AG000262
6 · The paper itself

Abstract

backgroundHip fractures are a public health problem among older adults, but most research on recovery after hip fracture has been limited to females. With growing numbers of hip fractures among males, it is important to determine how recovery outcomes may differ between the sexes.

methods168 males and 171 females were enrolled within 15 days of hospitalization with follow-up visits at 2, 6, and 12 months postadmission to assess changes in disability, physical performance, cognition, depressive symptoms, body composition, and strength, and all-cause mortality. Generalized estimating equations examined whether males and females followed identical outcome recovery assessed by the change in each outcome.

resultsThe mean age at fracture was similar for males (80.4) and females (81.4), and males had more comorbidities (2.5 vs 1.6) than females. Males were significantly more likely to die over 12 months (hazard ratio 2.89, 95% confidence interval: 1.56-5.34). Changes in outcomes were significantly different between males and females for disability, gait speed, and depressive symptoms (p < .05). Both sexes improved from baseline to 6 months for these measures, but only males continued to improve between 6 and 12 months. There were baseline differences for most body composition measures and strength; however, there were no significant differences in change by sex.

conclusionsFindings confirm that males have higher mortality but suggest that male survivors have continued functional recovery over the 12 months compared to females. Research is needed to determine the underlying causes of these sex differences for developing future prognostic information and rehabilitative interventions.

Indexed as

Hip FracturesSex CharacteristicsAgedFemaleHospitalizationHumansMaleRecovery of FunctionWalking SpeedBody compositionFunctionGait speedMortality

Identifiers

PMID34555162
PMCPMC9255694
OpenAlexW3201525752

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.