Evidence map›Paper›PMID 34555122›Full record

ArticlePloS one2021

Choroidal features in flat irregular pigment epithelial detachment associated with Chronic central serous chorioretinopathy: Avascular versus vascularized.

Hooshang Faghihi, Alireza Mahmoudi, Elias Khalili Pour, Nazanin Ebrahimiadib, Kaveh Fadakar, Fariba Ghassemi, Ahmad Mirshahi, Alireza Khodabande, Hassan Khojasteh, Fatemeh Bazvand and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Hooshang FaghihiRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Alireza MahmoudiRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Elias Khalili PourRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Nazanin EbrahimiadibRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Kaveh FadakarRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Fariba GhassemiRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Ahmad MirshahiRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Alireza KhodabandeRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Hassan KhojastehRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh BazvandRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mohammadreza Mehrabi BaharRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Hamid Riazi-EsfahaniRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0003-2277-398X
Farabi Hospital · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the differences in the choroidal biomarkers between two forms of flat irregular pigment epithelial detachment (FIPED): avascular (aFIPED) and vascularized (vFIPED) in eyes with chronic central serous chorioretinopathy (CSC). MATERIALS AND

methodsEnhanced depth imaging optical coherence tomography (EDI-OCT) was done in eyes with FIPED correlated to chronic CSC, fellow eyes, and also in healthy eyes from gender- and age-matched subjects. Eyes with FIPED were classified into two subgroups based on optical coherence tomography angiography (OCTA) findings: vFIPED and aFIPED. Different choroidal biomarkers such as subfoveal choroidal thickness (SFCT), total choroidal area (TCA), and choroidal vascular index (CVI) were compared between the groups.

resultsForty-four eyes from 42 patients with chronic CSC and FIPED along with 40 eyes from 20 healthy subjects were included. OCTA identified vascularization in 14 eyes in the FIPED group (31.8%). Mean SFCT was higher in the FIPED group compared to two other groups (p = 0.005). In comparison to patients with aFIPED, patients with vFIPED had lower SFCT (p = 0.003) and higher CVI (p = 0.020) based on multivariate analysis.

conclusionsIt seems that measurement of CVI along with SFCT may help to differentiate aFIPED from vFIPED in patients with CSC. Further longitudinal studies would be required to confirm the clinical significance of these findings.

Indexed as

AdultAgedCase-Control StudiesCentral Serous ChorioretinopathyChoroidHumansMiddle AgedRetinal DetachmentRetrospective StudiesTomography, Optical Coherence

Identifiers

PMID34555122
PMCPMC8459941
OpenAlexW3200419166

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.