ArticlePLoS neglected tropical diseases2021
Leishmania tarentolae and Leishmania infantum in humans, dogs and cats in the Pelagie archipelago, southern Italy.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence-Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis.Veterinary dermatology · 2025Guideline
- Canine Leishmaniasis in Europe over the Last Decade: A Review of Geographic Trends and Epidemiological Data.Pathogens (Basel, Switzerland) · 2025Pooled it
- qPCR as a Tool for the Diagnosis of Visceral and Cutaneous Leishmaniasis: A Systematic Review and Meta-Analysis.Acta parasitologica · 2025Pooled it
- LeishVet update and current recommendations on feline leishmaniosis.Parasites & vectors · 2026Review
- Performance assessment of a duplex quantitative PCR assay for detectingMicrobiology spectrum · 2026Article
- First epidemiological characterization of Leishmania tarentolae in sand flies collected in southern France and Corsica Island.PLoS neglected tropical diseases · 2026Article
- Updated Canine Leishmaniosis Working Group recommendations for leishmaniosis in dogs: Q&A on clinical management.Parasites & vectors · 2026Review
- Zoonotic leishmaniasis in China: Current status and challenges to elimination.PLoS neglected tropical diseases · 2026Review
- Revisiting the largest human leishmaniasis outbreak in Western Europe (Madrid, Spain): a follow-up entomological study in 2023 and 2024.Parasites & vectors · 2026Article
- Suramin Interactions Across Biological Systems: From Molecular Targets to Therapeutic Implications.Biomolecules · 2026Review
- Molecular diagnostics for cutaneous leishmaniasis: progress towards fulfilling the WHO target product profile.Parasitology · 2025Review
- Partners in time: Cospeciation and host-switching shape the evolution of Leishmania parasites.PLoS neglected tropical diseases · 2025Article
- Epidemiological dynamics ofMicrobial genomics · 2025Article
- High Seroprevalence of Feline Leishmaniosis (FeL) in Campania (Italy) Region: Current Epidemiological Scenario.Pathogens (Basel, Switzerland) · 2025Article
- Possible role of domestic cats in the epidemiology of leishmaniasis: evidence of genital lesions and vertical transmission.Veterinary research communications · 2025Article
- Leishmania (Leishmania) infantum and Leishmania (Sauroleishmania) tarentolae in outdoor cats and report of infection in feline-derived peripheral blood mononuclear cells.Parasites & vectors · 2025Article
- Development of a novel ddPCR assay for the simultaneous detection of the protozoan parasites Leishmania infantum and Leishmania tarentolae.Parasites & vectors · 2025Article
- Seroepidemiological Surveillance of Livestock Within an Endemic Focus of Leishmaniasis Caused byAnimals : an open access journal from MDPI · 2025Article
- Visceral Leishmaniasis in Pediatrics: A Case Series and a Narrative Review with Global Insights.Tropical medicine and infectious disease · 2025Review
- Sand Fly Fauna and Prevalence ofTransboundary and emerging diseases · 2025Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visceral leishmaniasis (VL) caused by Leishmania infantum is endemic in the Mediterranean basin with most of the infected human patients remaining asymptomatic. Recently, the saurian-associated Leishmania tarentolae was detected in human blood donors and in sheltered dogs. The circulation of L. infantum and L. tarentolae was investigated in humans, dogs and cats living in the Pelagie islands (Sicily, Italy) by multiple serological and molecular testing. Human serum samples (n = 346) were tested to assess the exposure to L. infantum by immunofluorescence antibody test (IFAT), enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) and to L. tarentolae by IFAT. Meanwhile, sera from dogs (n = 149) and cats (n = 32) were tested for both Leishmania species by IFAT and all blood samples, including those of humans, by specific sets of real time-PCR for L. infantum and L. tarentolae. The agreement between serological tests performed for human samples, and between serological and molecular diagnostic techniques for both human and animal samples were also assessed. Overall, 41 human samples (11.8%, 95% CI: 8.9-15.7) were positive to L. infantum (5.2%, 95% CI: 3.3-8.1), L. tarentolae (5.2%, 95% CI: 3.3-8.1) and to both species (1.4%, 95% CI: 0.6-3.3) by serology and/or molecular tests. A good agreement among the serological tests was determined. Both Leishmania spp. were serologically and/or molecularly detected in 39.6% dogs and 43.7% cats. In addition to L. infantum, also L. tarentolae circulates in human and animal populations, raising relevant public health implications. Further studies should investigate the potential beneficial effects of L. tarentolae in the protection against L. infantum infection.
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