ArticleEuropean journal of rheumatology2021
Use of non-TNF biologics for the treatment of neuro-Behçet's disease: Literature review and 2 refractory cases of monoclonal anti-TNFs treated with tocilizumab.
Article in European journal of rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Clinical characteristics of headache in the patients with Neuro-Behçet's disease.Acta neurologica Belgica · 2026Article
- Severe neuro-behçet's disease refractory: Radiologic improvement with tocilizumab.Radiology case reports · 2026Article
- Neuro-behcet's syndrome: epidemiology, mechanisms, and emerging strategies in diagnosis and treatment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurological complications of BD (neuro-Behçet's disease [NBD]) are life-threatening and disabling manifestations. Neurological involvement occurs in approximately 5% to 18% of patients with BD. Most patients with NBD respond well to glucocorticoids, cyclophosphamide, or anti-tumor necrosis factors (TNFs), but there are some resistant cases refractory to these drugs. This study aims to summarize the existing data on the management of NBD, with special focus on patients resistant to anti-TNFs. The study included a short review of early treatment steps. In addition to a literature review of treatment with non-TNF biologics, we present 2 NBD cases with neurological involvement that are resistant to standard high-dose steroid therapy and anti-TNF treatment. Both patients responded well to the tocilizumab therapy, and there was no serious adverse event.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.