Evidence map›Paper›PMID 34554650›Full record

ArticleBrain and behavior2021

Effects of the COVID-19 pandemic in a preexisting longitudinal study of patients with recently diagnosed bipolar disorder: Indications for increases in manic symptoms.

Manja Koenders, Rahele Mesbah, Annet Spijker, Elvira Boere, Max de Leeuw, Bert van Hemert, Erik Giltay

Open access · goldAbstract read
In one paragraph

Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Social Rhythms, Depressive Symptoms, and Quality of Life: An Unbreakable Bond in an Older Adult Sample.International journal of environmental research and public health · 2026
    Observational
  3. Article
  4. Review
  5. Observational
  6. Article
  7. Impact of the COVID-19 pandemic on patients with bipolar disorder in Japan.PCN reports : psychiatry and clinical neurosciences · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Manja KoendersDepartment of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0001-5908-258X
Rahele MesbahDepartment of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.
Annet SpijkerDepartment of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.
Elvira BoereDepartment of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.
Max de LeeuwDepartment of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.
Bert van HemertDepartment of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.
Erik GiltayDepartment of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.
Leiden University Medical Center · NLLeiden University · NL

Funding

Cella Durksz fund CWB 5267LUF/Gratama fund 2016-10 CWB 6515
6 · The paper itself

Abstract

backgroundThe coronavirus disease 2019 (COVID-19) pandemic interfered in the daily lives of people and is assumed to adversely affect mental health. However, the effects on mood (in)stability of bipolar disorder (BD) patients and the comparison to pre-COVID-19 symptom severity levels are unknown.

methodBetween April and September, 2020, symptoms and well-being were assessed in the Bipolar Netherlands Cohort (BINCO) study of recently diagnosed patients with BD I and II. The questionnaire contained questions regarding manic and depressive symptoms (YMRS and ASRM, QIDS), worry (PSWQ), stress (PSS), loneliness, sleep, fear for COVID-19, positive coping, and substance use. As manic, depressive and stress symptoms levels were assessed pre-COVID-19, their trajectories during the lockdown restrictions were estimated using mixed models.

resultsOf the 70 invited BD patients, 36 (51%) responded at least once (mean age of 36.7 years, 54% female, and 31% BD type 1) to the COVID-19 assessments. There was a significant increase (X

conclusionWe found a meaningful increase in manic symptomatology from pre-COVID-19 into the initial phases of the pandemic in BD patients. These symptoms decreased along with fear of COVID-19 and positive coping during the following months when lockdown measures were eased.

Indexed as

Bipolar DisorderCOVID-19AdultCommunicable Disease ControlFemaleHumansLongitudinal StudiesMalePandemicsSARS-CoV-2bipolar disorderCOVID-19depressionlonelinessmaniastress

Identifiers

PMID34554650
PMCPMC8613426
OpenAlexW3200344207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.