Evidence map›Paper›PMID 34554646›Full record

ArticleObesity (Silver Spring, Md.)2022

Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: A cross-sectional study.

Alessandro Domingues Heubel, Ariane Aparecida Viana, Stephanie Nogueira Linares, Vanessa Teixeira do Amaral, Nathany Souza Schafauser, Gustavo Yudi Orikassa de Oliveira, Paula Camila Ramírez, Bruno Martinelli, Tiago da Silva Alexandre, Audrey Borghi-Silva and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Alessandro Domingues HeubelCardiopulmonary Physiotherapy Laboratory, Department of Physical Therapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
Ariane Aparecida VianaExercise and Chronic Disease Research Laboratory, Department of Physical Education, School of Sciences, São Paulo State University, Bauru, São Paulo, Brazil.
Stephanie Nogueira LinaresCardiopulmonary Physiotherapy Laboratory, Department of Physical Therapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
Vanessa Teixeira do AmaralExercise and Chronic Disease Research Laboratory, Department of Physical Education, School of Sciences, São Paulo State University, Bauru, São Paulo, Brazil.
Nathany Souza SchafauserCardiopulmonary Physiotherapy Laboratory, Department of Physical Therapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
Gustavo Yudi Orikassa de OliveiraExercise and Chronic Disease Research Laboratory, Department of Physical Education, School of Sciences, São Paulo State University, Bauru, São Paulo, Brazil.
Paula Camila RamírezDepartment of Physical Therapy, Universidad Industrial de Santander, Bucaramanga, Santander, Colombia.
Bruno MartinelliDepartment of Physical Therapy, Sacred Heart University Center, Bauru, São Paulo, Brazil.
Tiago da Silva AlexandreDepartment of Gerontology, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
Audrey Borghi-SilvaCardiopulmonary Physiotherapy Laboratory, Department of Physical Therapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-3891-6941
Emmanuel Gomes CiolacExercise and Chronic Disease Research Laboratory, Department of Physical Education, School of Sciences, São Paulo State University, Bauru, São Paulo, Brazil.
Renata Gonçalves MendesCardiopulmonary Physiotherapy Laboratory, Department of Physical Therapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-4683-2657
Universidade Federal de São Carlos · BRUniversidade Estadual Paulista (Unesp) · BRIndustrial University of Santander · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to identify determinants of endothelial dysfunction in patients hospitalized with acute COVID-19.

methodsA total of 109 hospitalized COVID-19 patients in noncritical status were cross-sectionally studied. Clinical data (age, sex, comorbidities, and medications) and BMI were assessed. Laboratory tests included serum hemoglobin, leukocytes, lymphocytes, platelets, C-reactive protein, ferritin, D-dimer, and creatinine. Physical status was evaluated using a handgrip dynamometer. Endothelial function was assessed noninvasively using the flow-mediated dilation (FMD) method.

resultsThe sample average age was 51 years, 51% of patients were male, and the most frequent comorbidity was obesity (62%). Univariate analysis showed association of lower FMD with higher BMI, hypertension, use of oral antihypertensive, higher blood levels of creatinine, and larger baseline artery diameter. After adjusting for confounders, the multivariate analysis showed BMI (95% CI: -0.26 to -0.11; p < 0.001) as the major factor associated with FMD. Other factors associated with FMD were baseline artery diameter (95% CI: -1.77 to -0.29; p = 0.007) and blood levels of creatinine (95% CI: -1.99 to -0.16; p = 0.022).

conclusionsIncreased BMI was the major factor associated with endothelial dysfunction in noncritically hospitalized COVID-19 patients. This may explain one of the pathways in which obesity may increase the risk for severe COVID-19.

Indexed as

COVID-19Brachial ArteryCross-Sectional StudiesEndothelium, VascularHand StrengthHumansMaleMiddle AgedSARS-CoV-2Vasodilation

Identifiers

PMID34554646
PMCPMC8661847
OpenAlexW3200174346

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.