ArticleAdvanced materials (Deerfield Beach, Fla.)2021
Nature-Inspired Circular-Economy Recycling for Proteins: Proof of Concept.
Article in Advanced materials (Deerfield Beach, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Recent advances in designing high-performance and enzymatically degradable plastics.Chemical science · 2026Review
- Photon-to-Heat Energy Harvesting Fluorescent Protein Coatings for Thermoelectrics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Amyloid-Like Self-Assembling of Black Soldier Fly Proteins and Development of Bioplastics.ACS sustainable chemistry & engineering · 2025Article
- Bright Thermo-resilient and Promiscuous Zombie Protein for Lighting Applications.ACS materials letters · 2025Article
- Additive Manufacturing of Lignocellulosic Aerogels from Minimally Processed Waste Streams.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Building a Synthetic Cell Together.Nature communications · 2025Review
- Recycled Sericin Biopolymer in Biotechnology and Bioelectronics.Bioengineering (Basel, Switzerland) · 2025Review
- Nature-inspired recycling of a protein mixture into a green fluorescent protein-based hydrogel.RSC sustainability · 2024Article
- On biochemical constructors and synthetic cells.Interface focus · 2023Article
- Recycling of Polymerase Chain Reaction (PCR) Kits.ACS sustainable chemistry & engineering · 2023Article
- The Long Road to a Synthetic Self-Replicating Central Dogma.Biochemistry · 2023Review
- Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films.Nanomaterials (Basel, Switzerland) · 2022Article
- Nature-Inspired Circular-Economy Recycling for Proteins: Proof of Concept.Advanced materials (Deerfield Beach, Fla.) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
The billion tons of synthetic-polymer-based materials (i.e. plastics) produced yearly are a great challenge for humanity. Nature produces even more natural polymers, yet they are sustainable. Proteins are sequence-defined natural polymers that are constantly recycled when living systems feed. Digestion is the protein depolymerization into amino acids (the monomers) followed by their re-assembly into new proteins of arbitrarily different sequence and function. This breaks a common recycling paradigm where a material is recycled into itself. Organisms feed off of random protein mixtures that are "recycled" into new proteins whose identity depends on the cell's specific needs. In this study, mixtures of several peptides and/or proteins are depolymerized into their amino acid constituents, and these amino acids are used to synthesize new fluorescent, and bioactive proteins extracellularly by using an amino-acid-free, cell-free transcription-translation (TX-TL) system. Specifically, three peptides (magainin II, glucagon, and somatostatin 28) are digested using thermolysin first and then using leucine aminopeptidase. The amino acids so produced are added to a commercial TX-TL system to produce fluorescent proteins. Furthermore, proteins with high relevance in materials engineering (β-lactoglobulin films, used for water filtration, or silk fibroin solutions) are successfully recycled into biotechnologically relevant proteins (fluorescent proteins, catechol 2,3-dioxygenase).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.