Evidence map›Paper›PMID 34554568›Full record

ArticleMedical physics2021

X-ray bi-prism interferometry-A design study of proposed novel hardware.

Grant T Gullberg, Uttam Shrestha, Sally Ji Who Kim, Youngho Seo, Michael Fuller

Abstract read
In one paragraph

Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Grant T GullbergDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Uttam ShresthaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Sally Ji Who KimCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Michael FullerTF Instruments, Salinas, California, USA.

Funding

Energy-independent single photon molecular imaging technologyR01EB026331 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CUI, YONGGANG, SEO, YOUNGHO · 2018 to 2022
$2.6M
Dynamic cardiac SPECTR01HL135490 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GULLBERG, GRANT T, SEO, YOUNGHO · 2017 to 2020
$2.4M
Preclinical Dark-Field/Phase-Contrast Scanner Using X-ray BiprismsR43EB027535 · NIBIB · TF INSTRUMENTS · PI FULLER, MICHAEL KEITH, SEO, YOUNGHO · 2018 to 2018
$225k
NHLBI NIH HHS R01 HL135490NIBIB NIH HHS R01 EB026331NIBIB NIH HHS R43 EB027535NIH HHS R01 EB026331NIH HHS R01 HL135490NIH HHS R43 EB027535
6 · The paper itself

Abstract

purposeAdvances in X-ray phase-contrast imaging can obtain excellent soft-tissue contrast of phase-shift, attenuation, and small-angle scatter. Here, we present fringe patterns for different design parameters of X-ray bi-prism interferometry imaging systems. Our aim is to develop bi-prism interferometry imaging systems with excellent polychromatic performance that produce high-contrast fringes with spatially incoherent X-ray illumination. We also introduce a novel X-ray tube design that uses temporal multiplexing to provide simultaneous virtual "electronic phase stepping" that replace "mechanical phase stepping" popular with grating-based interferometry setups.

methodsIn our investigation, we develop expressions for the irradiance distribution pattern of a bi-prism interferometer composed of multiple point sources and multiple bi-prisms. These expressions are used to plot fringe patterns for X-ray design parameters, including size of point source, number of point sources, and point source separation, and bi-prism design parameters including material, angle, number of bi-prisms, period, and bi-prism array to X-ray source and detector distances.

resultsResults show that the fringe patterns for a bi-prism interferometry system are not longitudinally periodic as with grating interferometers that produce a Talbot-Lau carpet. It is also shown that at 59 keV X-rays the bi-prism material should be something comparable to nickel to obtain reasonable fringe visibility.

conclusionThe irradiance distribution pattern demonstrates that bi-prism interferometry may provide comparable or improved fringe visibility to that of gratings. Special care is given to present our findings within the context of previous advancements. A single-shot image acquisition approach using a temporal multiplexed, high-power X-ray source provides virtual electronic phase stepping without focal spot sweeping. This provides multiple images, each at the same exposure and the same projection view, from different fringe locations that allow one to derive the attenuation, phase, and dark-field images of the sample without mechanical phase stepping of a grating.

Indexed as

InterferometryRadiographyX-Raysbi-prism interferometrydark-field imagingsmall-angle scatterX-ray phase-contrast imagingX-ray tube design

Identifiers

PMID34554568
PMCPMC8614238

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.