Evidence map›Paper›PMID 34554512›Full record

ArticleBiologia futura2020

Whey protein concentrate protects against age-dependent alteration in redox biomarkers.

Geetika Garg, Abhishek Kumar Singh, Sandeep Singh, Avnish Kumar Verma, Syed Ibrahim Rizvi

Abstract read
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In one paragraph

Article in Biologia futura, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Geetika GargDepartment of Biochemistry, University of Allahabad, Allahabad, 211002, India.
Abhishek Kumar SinghDepartment of Biochemistry, University of Allahabad, Allahabad, 211002, India.
Sandeep SinghDepartment of Biochemistry, University of Allahabad, Allahabad, 211002, India.
Avnish Kumar VermaDepartment of Biochemistry, University of Allahabad, Allahabad, 211002, India.
Syed Ibrahim RizviDepartment of Biochemistry, University of Allahabad, Allahabad, 211002, India. sirizvi@gmail.com.ORCID http://orcid.org/0000-0001-8978-825X
University of Allahabad · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is associated with decreased cellular cysteine uptake, which acts as a precursor for glutathione biosynthesis. Whey protein, a liquid aspect of milk, is an effective cysteine delivery system. The study was undertaken to evaluate the potential role of whey protein concentrate (WPC) on the redox biomarkers during aging. Male Wistar rats were divided into following four groups: young control (4 months old); young treated with WPC (300 mg/kg b.w./day orally); old (24 months old) control; old treated with WPC for 28 days. After treatment, changes in body weight, lipid profile and levels of redox biomarkers were determined. A marked decrease in prooxidants such as reactive oxygen species, lipid peroxidation and protein carbonyl and significant (p ≤ 0.05) increase in antioxidants such as reduced glutathione and GST levels were observed after WPC supplementation in old age rats. We also found marked decrease in the level of sialic acid and AGEs after WPC supplementation. In conclusion, WPC provides protection against age-dependent redox imbalance which might be attributed to its antioxidant activity.

Indexed as

AgingAnimalsBiomarkersCysteineDrug Evaluation, PreclinicalErythrocytesGlycation End Products, AdvancedLipid MetabolismMaleOxidative StressRats, WistarReactive Oxygen SpeciesTryptophanTyrosineWhey ProteinsBiomarkersCysteinedityrosineGlycation End Products, AdvancedReactive Oxygen SpeciesTryptophanTyrosineWhey ProteinsAgingErythrocytesL-cysteine influxLipid profileOxidative stressWhey protein

Identifiers

PMID34554512
OpenAlexW3045563132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.