ArticleBiologia futura2019
The effect of swimming training on oxidative stress, SIRT1 gene expression, and histopathology of hepatic tissue in type 2 diabetic rats.
Article in Biologia futura, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 10 citations in OpenAlex.
- Type 2 Diabetes Mellitus Provokes Rat Immune Cells Recruitment into the Pulmonary Niche by Up-regulation of Endothelial Adhesion Molecules.Advanced pharmaceutical bulletin · 2022Article
- Voluntary exercise improves spermatogenesis and testicular apoptosis in type 2 diabetic rats through alteration in oxidative stress and mir-34a/SIRT1/p53 pathway.Iranian journal of basic medical sciences · 2021Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
introductionElevated oxidative stress in type 2 diabetes mellitus (T2DM) has been proposed as one of the major risk factors in pathophysiology of several organ damages including liver tissue. MATERIALS AND
methodsIn this study, we evaluated the effect of swimming training on hepatic oxidative markers, SIRT1 gene expression, and histological alterations in T2DM. Twenty-eight male Wistar rats were randomly assigned into four groups (N=7): control, exercise, diabetic, and diabetic + exercise. One week after the induction of T2DM, rats were subjected to swimming (60 min/5 days a week) for 12 weeks. At the end of the experiment, oxidative markers (SOD, GPx, CAT activities, and MDA level) and SIRT1 gene expression were measured in the liver by special kits and RT-PCR, respectively. Hematoxylin-eosin statins were used for histological alterations.
resultsSwimming training attenuated MDA levels and enhanced SOD, GPx, and CAT activities in the liver of diabetic animals. Furthermore, swimming training restored the expression of SIRT1 in T2DM. Histopathological finding of the hepatic tissue confirmed a protective role for swimming training in diabetic rats.
conclusionOur findings indicate that swimming training attenuates oxidative stress probably by upregulation of SIRT1 in the liver of type 2 diabetic rats.
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