Evidence map›Paper›PMID 34554406›Full record

SynthesisAmerican journal of clinical dermatology2021

Psychosocial Effects of Vitiligo: A Systematic Literature Review.

Khaled Ezzedine, Viktoria Eleftheriadou, Heather Jones, Kristen Bibeau, Fiona I Kuo, Daniel Sturm, Amit G Pandya

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in American journal of clinical dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 4 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 4 syntheses or guidelines pooled it, 232 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. The humanistic burden of vitiligo: a systematic literature review of quality-of-life outcomes.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022
    Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Methodological strategies for mappingWorld journal of methodology · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Khaled EzzedineDepartment of Dermatology, Henri Mondor University Hospital and Université Paris-Est Créteil Val de Marne, 51 Avenue du Maréchal de Lattre de Tassigny, Créteil, 94010, Paris, France. khaled.ezzedine@aphp.fr.
Viktoria EleftheriadouDepartment of Dermatology, Queen Elizabeth Hospital, Birmingham, UK.
Heather JonesIncyte Corporation, Wilmington, DE, USA.
Kristen BibeauIncyte Corporation, Wilmington, DE, USA.
Fiona I KuoIncyte Corporation, Wilmington, DE, USA.
Daniel SturmIncyte Corporation, Wilmington, DE, USA.
Amit G PandyaPalo Alto Foundation Medical Group, Mountain View, CA, USA.
Incyte (United States) · USHôpitaux Universitaires Henri-Mondor · FRQueen Elizabeth Hospital Birmingham · GBThe University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with vitiligo experience reduced quality of life.

objectiveTo comprehensively describe the available evidence for psychosocial burden in vitiligo.

methodsA systematic review of observational studies and clinical trials identified using PubMed, EMBASE, Scopus, and the Cochrane databases was performed through 1 March, 2021, to assess psychosocial comorbidities in vitiligo. Two independent reviewers performed an assessment of articles and extracted data for qualitative synthesis.

resultsIncluded studies (N = 168) were published between 1979 and 1 March, 2021; 72.6% were published since 2010. Disorders including or related to depression (41 studies, 0.1-62.3%) and anxiety (20 studies, 1.9-67.9%) were the most commonly reported. The most prevalent psychosocial comorbidities were feelings of stigmatization (eight studies, 17.3-100%), adjustment disorders (12 studies, 4-93.9%), sleep disturbance (seven studies, 4.6-89.0%), relationship difficulties including sexual dysfunction (ten studies, 2.0-81.8%), and avoidance or restriction behavior (12.5-76%). The prevalence of most psychosocial comorbidities was significantly higher vs healthy individuals. Factors associated with a significantly higher burden included female sex, visible or genital lesions, age < 30 years (particularly adolescents), and greater body surface area involvement, among others. The most commonly reported patient coping strategy was lesion concealment. LIMITATIONS: Available studies were heterogeneous and often had limited details; additionally, publication bias is possible.

conclusionsThe results of this systematic review show that vitiligo greatly affects psychosocial well-being. The extent of psychosocial comorbidities supports the use of multidisciplinary treatment strategies and education to address the vitiligo-associated burden of disease. PROTOCOL REGISTRATION: PROSPERO (CRD42020162223).

Indexed as

Quality of LifeSocial StigmaAdaptation, PsychologicalAdjustment DisordersAge FactorsBody Surface AreaClinical Trials as TopicComorbidityFemaleHumansMaleObservational Studies as TopicPersonality DisordersPrevalenceRisk FactorsSeverity of Illness Index

Identifiers

PMID34554406
PMCPMC8566637
OpenAlexW3199110510

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.