Evidence map›Paper›PMID 34554354›Full record

ArticleLasers in medical science2022

Effects of photobiomodulation therapy in chondrocyte response by in vitro experiments and experimental model of osteoarthritis in the knee of rats.

Carla Roberta Tim, Cintia Cristina Santi Martignago, Lívia Assis, Lia Mara Neves, Ana Laura Andrade, Naldiana Cerqueira Silva, Nivaldo Parizotto, Karina Zambone Pinto, Ana Claudia Rennó

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In one paragraph

Article in Lasers in medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

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  10. Photobiomodulation in Promoting Cartilage Regeneration.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Carla Roberta TimDepartment of Biomedical Engineering, Institute of Science and Technology of Brasil University, Carolina Fonseca, São Paulo, SP, 235, Brazil. carlinha_tim@hotmail.com.ORCID http://orcid.org/0000-0002-4745-9375
Cintia Cristina Santi MartignagoDepartment of Physiotherapy, Federal University of São Carlos, Rod. Washington Luis, São Carlos, SP, 235, Brazil.
Lívia AssisDepartment of Biomedical Engineering, Institute of Science and Technology of Brasil University, Carolina Fonseca, São Paulo, SP, 235, Brazil.
Lia Mara NevesDepartment of Physiology, Federal University of São Carlos, Rod. Washington Luis, São Carlos, SP, 235, Brazil.
Ana Laura AndradeDepartment of Physiotherapy, Federal University of São Carlos, Rod. Washington Luis, São Carlos, SP, 235, Brazil.
Naldiana Cerqueira SilvaDepartment of Biomedical Engineering, Institute of Science and Technology of Brasil University, Carolina Fonseca, São Paulo, SP, 235, Brazil.
Nivaldo ParizottoDepartment of Biomedical Engineering, Institute of Science and Technology of Brasil University, Carolina Fonseca, São Paulo, SP, 235, Brazil.
Karina Zambone PintoDepartments of Morphology and Pathology, Federal University of São Carlos, Rod. Washington Luis, São Carlos, SP, 235, Brazil.
Ana Claudia RennóDepartment of Bioscience, Federal University of São Paulo, Rua Silva Jardim, Santos, SP, 136, Brazil.
Universidade Brasil · BRUniversidade Federal de São Carlos · BRMorpho (United States) · USUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study is to evaluate the effects of photobiomodulation (PBM) therapy in chondrocyte response by in vitro experiments and cartilage repair using an experimental model of osteoarthritis (OA) in the knee of rats. The in vitro experiment was performed with chondrocyte cells, and they were divided into two groups: non-irradiated and irradiated with PBM (808 nm; 0.8 J or 1.4 J). Then, cell proliferation was evaluated after 1, 3, and 5 days. The experimental model of osteoarthritis (OA) was performed in the knee of 64 Wistar rats, and they were assorted into control group (CG), PBM (808 nm; 1.4 J). The results of in vitro showed that PBM 1.4 J increased cell proliferation, on days 1 and 5. However, after 3 days was demonstrated a significant increase in cell proliferation in PBM 0.8 J. The in vivo experiment results demonstrated, on histological analysis, that PBM presented less intense signs of tissue degradation with an initial surface discontinuity at the superficial zone and disorganization of the chondrocytes in the cartilage region when compared to CG, after 4 and 8 weeks. These findings were confirmed by immunohistochemistry and qRT-PCR analysis which showed that PBM increased IL-4, IL-10, COL-2, Aggrecan, and TGF-β which are anabolic factors and acts on extracellular matrix. Also, PBM reduces the IL1-β, an inflammatory marker that operates as a catabolic factor on articular cartilage. In conclusion, these results suggest that PBM may have led to a return to tissue homeostasis, promoting chondroprotective effects and stimulating the components of the articular tissue.

Indexed as

Cartilage, ArticularLow-Level Light TherapyOsteoarthritisOsteoarthritis, KneeAnimalsChondrocytesDisease Models, AnimalRatsRats, WistarArticular cartilageKnee osteoarthritisLaserPhotobiomodulation

Identifiers

PMID34554354
OpenAlexW3199314453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.