ArticlePediatric surgery international2022
Is the appendix a good organ to diagnose total colonic aganglionosis?
Article in Pediatric surgery international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Appendix tip biopsy for Total colonic aganglionosis: technical aspects and diagnostic accuracy in a prospective cohort of 107 pediatric patients.Pediatric surgery international · 2026Observational
- Surgical pathology of Hirschsprung disease (HSCR).World journal of pediatric surgery · 2025Review
- A Rare Case Presentation on Total Colonic Aganglionosis in a Female Infant of Indian Origin.Cureus · 2023Article
- Hirschsprung disease.Nature reviews. Disease primers · 2023Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe use of the appendix for diagnosis of Total Colonic Aganglionosis (TCA) remains controversial. This study aimed to categorize the presence of ganglion cells in the appendix and determine its reliability as a histological specimen for the diagnosis of TCA.
methodsThis was a combined retrospective and prospective study. Permanent histological specimens of normal appendices removed during appendectomy for malrotation or falsely presumed appendicitis, and from patients with short segment Hirschsprung's disease (HD) or TCA were included. Permanent specimens of the appendix tip from Malone procedures were prospectively collected. All specimens were independently reviewed by two experienced pathologists in a standardized manner to assess for the presence of ganglion cells.
resultsA total of 112 appendices were evaluated. Nine came from patients with a diagnosis of TCA, and five from patients with HD. Ganglion cells were present in all specimens from patients with diagnoses other than TCA and were absent in all specimens from patients with TCA.
conclusionIn the correct clinical setting, the absence of ganglion cells in the appendix can allow for a reliable diagnosis of TCA.
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