Evidence map›Paper›PMID 34554249›Full record

ReviewClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Antibiotic Overuse and Stewardship at Hospital Discharge: The Reducing Overuse of Antibiotics at Discharge Home Framework.

Valerie M Vaughn, Adam L Hersh, Emily S Spivak

Registry-linked trialAbstract readReview
In one paragraph

Review in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06106204 (A Parallel Cluster Randomized Trial of a Participatory Approach to Reduce Overuse of Antibiotics at Hospital Discharge), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06106204 naenrolling by invitationnot on this mapstarted 2023, after this paper: background citation

A Parallel Cluster Randomized Trial of a Participatory Approach to Reduce Overuse of Antibiotics at Hospital Discharge: The ROAD Home Trial

TypeinterventionalSponsorUniversity of UtahRan2023 to 2028Enrolled40ConditionsPneumonia, Urinary Tract Infection, Antibiotic Stewardship, Care TransitionArmsROAD Home Intervention
3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Prolonged antibiotic treatment durations for community-onset infections in Dutch hospitals.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. A Novel LyticFoods (Basel, Switzerland) · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Unraveling indications for discharge antibiotics: the Devil's in the details.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025
    Article
  17. Article
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Valerie M VaughnDivision of General Internal Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Adam L HershDivision of Infectious Diseases, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Emily S SpivakDivision of Infectious Diseases, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Funding

Engaging Hospitalists to Improve Antibiotic Prescribing at Hospital DischargeK08HS026530 · AHRQ · UNIVERSITY OF UTAH · PI VAUGHN, VALERIE MICHELE · 2020 to 2024
$765k
AHRQ HHS K08 HS026530
6 · The paper itself

Abstract

Though opportunities exist to improve antibiotic prescribing across the care spectrum, discharge from acute hospitalization is an increasingly recognized source of antibiotic overuse. Antimicrobials are prescribed to more than 1 in 8 patients at hospital discharge; approximately half of which could be improved. Key targets for antibiotic stewardship at discharge include unnecessary antibiotics, excess duration, avoidable fluoroquinolones, and improving (or avoiding) intravenous antibiotic therapy. Barriers to discharge antibiotic stewardship include the perceived "high stakes" of care transitions during which patients move from intense to infrequent observation, difficulties in antibiotic measurement to guide improvement at discharge, and poor communication across silos, particularly with skilled nursing facilities. In this review, we discuss what is currently known about antibiotic overuse at hospital discharge, key barriers, and targets for improving antibiotic prescribing at discharge and we introduce an evidence-based framework, the Reducing Overuse of Antibiotics at Discharge Home Framework, for conducting discharge antibiotic stewardship.

Indexed as

Anti-Bacterial AgentsAntimicrobial StewardshipHospitalsHumansPatient DischargeSkilled Nursing FacilitiesAnti-Bacterial Agentsantibiotic stewardshipcare transitiondischargeinfection

Identifiers

PMID34554249
PMCPMC9070833

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.