ArticleBehavioral neuroscience2022
Individual differences in neurocognitive aging in outbred male and female long-evans rats.
Article in Behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Biological sex and normative cognitive aging across spatial learning, flexibility, and working memory in Fischer 344 rats.Behavioral neuroscience · 2026Article
- When Familiar Faces Feel Better: A Framework for Social Neurocognitive Aging in a Rat Model.eNeuro · 2026Article
- The 3D Vertical Maze: A new model system for studying the interactions between social and spatial cognition.Journal of neuroscience methods · 2025Article
- Normal and slow learners: a new discriminative method based on the speed of spatial learning in aged mice.Frontiers in aging neuroscience · 2025Article
- Intermittent working memory training during adulthood protects against age-related long-term spatial reference memory decline in rats.GeroScience · 2024Article
- Alzheimer's therapeutic development: shifting neurodegeneration to neuroregeneration.Trends in pharmacological sciences · 2024Review
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Authors and funding
3 authors.
Funding
Abstract
Individual differences in biology as well as experience and exposures throughout life may contribute risk or resilience to neurocognitive decline in aging. To investigate the role of sex as a biological variable in cognitive function due to normal aging, we used substantial cohorts of healthy male and female aged outbred rats maintained under similar conditions throughout life to assess whether both sexes display a similar distribution of individual differences in behavioral performance using a water maze task optimized to assess hippocampal-dependent cognition in aging. We found both aged male and female rats performed poorer than young adults overall, but with no performance differences between sex in either young adults or aged groups in memory probe tests. In addition, aged male and female rats had similar distributions of individual differences such that the same proportion of male and female performed on par with (intact memory) or outside of (impaired memory) the benchmark of young rats of their respective sex. The data support the use of this outbred model with biological diversity to study the neurobiology of aging trajectories for variation in cognitive outcomes in both male and females. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
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