Evidence map›Paper›PMID 34553961›Full record

ArticleJournal of abnormal psychology2021

Repetitive behavior with objects in infants developing autism predicts diagnosis and later social behavior as early as 9 months.

Meghan Miller, Shuai Sun, Ana-Maria Iosif, Gregory S Young, Ashleigh Belding, Andrew Tubbs, Sally Ozonoff

Open access · hybridAbstract read
In one paragraph

Article in Journal of abnormal psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Research square · 2026
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  8. Review
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  13. Embedding Play to Enrich Physical Therapy.Behavioral sciences (Basel, Switzerland) · 2023
    Article
  14. Review
  15. Article
  16. Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study.Autism research : official journal of the International Society for Autism Research · 2022
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Meghan MillerMIND Institute.ORCID 0000-0002-1260-4149
Shuai SunGraduate Group in Biostatistics.ORCID 0000-0002-8810-3690
Ana-Maria IosifDepartment of Public Health Sciences, Division of Biostatistics.ORCID 0000-0001-7283-2015
Gregory S YoungMIND Institute.ORCID 0000-0002-2515-5979
Ashleigh BeldingMIND Institute.ORCID 0000-0001-8017-9992
Andrew TubbsMIND Institute.ORCID 0000-0003-3799-5972
Sally OzonoffMIND Institute.ORCID 0000-0002-1230-0794
University of California, Davis · USCancer Research And Biostatistics · US

Funding

Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JUDY A. VAN DE WATER · 2020 to 2026
$9.7M
Infants at Risk of Autism: A Longitudinal StudyR01MH068398 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI OZONOFF, SALLY · 2003 to 2013
$6.1M
An investigation of transdiagnostic mechanisms underlying ASD and ADHD traits among infants at riskR01MH121416 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MILLER, MEGHAN RHYS · 2020 to 2024
$3.9M
National Institute of Child Health and Human Development Intellectual and Developmental Disabilities Research CenterNICHD NIH HHS P50 HD103526NIMH NIH HHS R01 MH068398
6 · The paper itself

Abstract

We evaluated repetitive behavior with objects in infants at risk for autism spectrum disorder (ASD) from 9 to 36 months of age, and associations between early repetitive behavior and social engagement. Infant siblings of children with ASD (high-risk) or typical development (low-risk) were administered a task eliciting repetitive object use at 9, 12, 15, 18, 24, and 36 months of age. Infants (n = 147) were classified into 1 of 3 outcome groups at 36 months: Low-Risk Non-ASD (n = 58), High-Risk Non-ASD (n = 72), and ASD (n = 17). Behavior was coded from video for frequencies of unusual visual inspection, spinning, and rotating behaviors. Differences in unusual visual inspection were most prominent, consistent, and present earliest: At 9 months, the ASD group engaged in this behavior more frequently than both other groups, persisting through 36 months. Differences in frequencies of spinning and rotating were later-appearing, more time-limited, and/or related to familial ASD risk rather than ultimate diagnosis. Sensitivity and specificity estimates for the presence of unusual visual inspection at 9 months of age were in the moderate range (.60 and .68, respectively) for ASD versus Low-Risk Non-ASD comparisons, generally increasing over time. Unusual visual inspection at 9 months predicted 12-month social behavior controlling for 9-month social behavior, but not vice versa, with no evidence of moderation by ASD diagnosis. In summary, unusual visual inspection of objects is present and stable by 9 months of age in infants developing ASD and predicts reduced social engagement three-months later. Close monitoring of this behavior may aid early detection. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Indexed as

Autism Spectrum DisorderAutistic DisorderChildHumansInfantProspective StudiesSiblingsSocial Behavior

Identifiers

PMID34553961
PMCPMC8480432
OpenAlexW3201563029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.