Evidence map›Paper›PMID 34553780›Full record

ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2022

Fully Automated Placental Volume Quantification From 3D Ultrasound for Prediction of Small-for-Gestational-Age Infants.

Nadav Schwartz, Ipek Oguz, Jiancong Wang, Alison Pouch, Natalie Yushkevich, Shobhana Parameshwaran, James Gee, Paul Yushkevich, Baris Oguz

Abstract read
In one paragraph

Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Emerging applications of artificial intelligence for obstetric ultrasound: A scoping review.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
  5. SEGMENTATION CONFIDENCE FOR ARBITRARY CNNS.Proceedings. IEEE International Symposium on Biomedical Imaging · 2026
    Article
  6. PRISM Lite: A lightweight model for interactive 3D placenta segmentation in ultrasound.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  7. Interactive Segmentation Model for Placenta Segmentation from 3D Ultrasound images.Simplifying medical ultrasound : 5th international workshop, ASMUS 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 6, 2024, proceedings. ASMUS (Workshop) (5th : 2024 : Marrakech, Morocco) · 2025
    Article
  8. Review
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nadav SchwartzMaternal and Child Health Research Program, Department of OBGYN, University of Pennsylvania, Philadelphia, PA, USA.
Ipek OguzDepartment of EECS, Vanderbilt University, Nashville, TN, USA.
Jiancong WangPenn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Alison PouchPenn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Natalie YushkevichPenn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Shobhana ParameshwaranMaternal and Child Health Research Program, Department of OBGYN, University of Pennsylvania, Philadelphia, PA, USA.
James GeePenn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Paul YushkevichPenn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Baris OguzPenn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0002-0277-0100

Funding

Developing a multi-modality, paradigm-shifting approach for in vivo assessment of the human placenta and the impact of maternal nutrition on its development and functionU01HD087180 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI LICHT, DANIEL JACQUES, SCHWARTZ, NADAV · 2015 to 2015
$4.3M
Adaptive Large-Scale Framework for Automatic Biomedical Image SegmentationR01EB017255 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI YUSHKEVICH, PAUL A. · 2014 to 2018
$3.0M
Early detection of Huntington's Disease: Longitudinal analysis of basal ganglia and cortical thicknessR01NS094456 · NINDS · VANDERBILT UNIVERSITY · PI OGUZ, IPEK · 2016 to 2019
$1.3M
Placental morphology and serum biomarkers to predict adverse pregnancy outcomeR03HD069742 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI SCHWARTZ, NADAV · 2012 to 2013
$156k
Fully Automated 4D Echocardiographic Mitral Valve Analysis for Surgical RepairF32HL119010 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI POUCH, ALISON MARIE · 2013 to 2015
$153k
NHLBI NIH HHS F32 HL119010NIBIB NIH HHS R01 EB017255NICHD NIH HHS R03 HD069742NICHD NIH HHS U01 HD087180NIH HHS F32 HL119010NIH HHS R01 EB017255NIH HHS R01 NS094456NINDS NIH HHS R01 NS094456
6 · The paper itself

Abstract

objectivesEarly placental volume (PV) has been associated with small-for-gestational-age infants born under the 10th/5th centiles (SGA10/SGA5). Manual or semiautomated PV quantification from 3D ultrasound (3DUS) is time intensive, limiting its incorporation into clinical care. We devised a novel convolutional neural network (CNN) pipeline for fully automated placenta segmentation from 3DUS images, exploring the association between the calculated PV and SGA.

methodsVolumes of 3DUS obtained from singleton pregnancies at 11-14 weeks' gestation were automatically segmented by our CNN pipeline trained and tested on 99/25 images, combining two 2D and one 3D models with downsampling/upsampling architecture. The PVs derived from the automated segmentations (PV

resultsWe included 442 subjects with 37 (8.4%) and 18 (4.1%) SGA10/SGA5 infants, respectively. Our segmentation pipeline achieved a mean Dice score of 0.88 on an independent test-set. Adjusted models including PV

conclusionsFirst trimester PV measurements derived from our CNN segmentation pipeline are significantly associated with future SGA. This fully automated tool enables the incorporation of including placental volumetric biometry into the bedside clinical evaluation as part of a multivariable prediction model for risk stratification and patient counseling.

Indexed as

PlacentaUltrasonography, PrenatalFemaleGestational AgeHumansInfant, NewbornInfant, Small for Gestational AgePregnancyPregnancy Trimester, First3DUSconvolutional neural networksdeep learningplacentasmall-for-gestational-age

Identifiers

PMID34553780
PMCPMC8940735

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.