Evidence map›Paper›PMID 34553686›Full record

ArticleeLife2021

Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size.

Alessandro Bonfini, Adam J Dobson, David Duneau, Jonathan Revah, Xi Liu, Philip Houtz, Nicolas Buchon

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Cytoplasmic fluidity couples nutrient availability and enterocyte fate in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  7. Microbes and diet reshape the intestine via distinct cellular dynamics.bioRxiv : the preprint server for biology · 2025
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  16. FastiScience · 2023
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alessandro BonfiniCornell Institute of Host-Microbe Interactions and Disease, Department of Entomology, Cornell University, Ithaca, United States.ORCID 0000-0001-6642-8665
Adam J DobsonInstitute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0003-1541-927X
David DuneauUniversité Toulouse 3 Paul Sabatier, CNRS, UMR5174 EDB (Laboratoire Évolution & Diversité Biologique), Toulouse, France.ORCID 0000-0002-8323-1511
Jonathan RevahCornell Institute of Host-Microbe Interactions and Disease, Department of Entomology, Cornell University, Ithaca, United States.
Xi LiuCornell Institute of Host-Microbe Interactions and Disease, Department of Entomology, Cornell University, Ithaca, United States.
Philip HoutzCornell Institute of Host-Microbe Interactions and Disease, Department of Entomology, Cornell University, Ithaca, United States.
Nicolas BuchonCornell Institute of Host-Microbe Interactions and Disease, Department of Entomology, Cornell University, Ithaca, United States.ORCID 0000-0003-3636-8387

Funding

Gut microbes modulate immune pathways in intestinal stem cells to influence their lineageR01AI148541 · NIAID · CORNELL UNIVERSITY · PI BUCHON, NICOLAS · 2020 to 2024
$2.9M
The taste and smell of intestinal stem cells and its impact on proliferation and lifespanR21AG065733 · NIA · CORNELL UNIVERSITY · PI BUCHON, NICOLAS · 2020 to 2021
$432k
Medical Research Council MR/S033939/1NIAID NIH HHS R01 AI148541
6 · The paper itself

Abstract

The gut is the primary interface between an animal and food, but how it adapts to qualitative dietary variation is poorly defined. We find that the

Indexed as

DietAnimalsAnimals, Genetically ModifiedCell ProliferationDrosophila melanogasterEnterocytesFemaleGastrointestinal TractMaleStem Cell Nichecell sizedevelopmental biologydietD. melanogastergut growthintestinal stem cellorgan plasticityregenerative medicineshrinkagestem cell-niche couplingstem cells

Identifiers

PMID34553686
PMCPMC8528489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.