Evidence map›Paper›PMID 34553672›Full record

ArticleGut microbes

Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing

Rika Hirano, Mikiyasu Sakanaka, Kazuto Yoshimi, Naohisa Sugimoto, Syogo Eguchi, Yuko Yamauchi, Misaki Nara, Shingo Maeda, Yuta Ami, Aina Gotoh and 10 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

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  11. The state of play of rodent models for the study ofJournal of medical microbiology · 2024
    Review
  12. Review
  13. Development of an improved colonization system for human-derivedBioscience of microbiota, food and health · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 1 country.

Rika HiranoResearch Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.
Mikiyasu SakanakaResearch Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.
Kazuto YoshimiDivision of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, the University of Tokyo, Minato-ku, Tokyo, Japan.
Naohisa SugimotoFaculty of Agriculture, Niigata University, Niigata, Japan.
Syogo EguchiFaculty of Agriculture, Niigata University, Niigata, Japan.
Yuko YamauchiDivision of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, the University of Tokyo, Minato-ku, Tokyo, Japan.
Misaki NaraResearch Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.
Shingo MaedaResearch Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.
Yuta AmiFaculty of Biology-Oriented Science and Technology, Kindai University, Kinokawa, Wakayama, Japan.
Aina GotohGraduate School of Biostudies, Kyoto University, Kyoto, Japan.
Takane KatayamaResearch Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.
Noriho IidaDepartment of Gastroenterology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.
Tamotsu KatoLaboratory for Intestinal Ecosystem, Riken Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Hiroshi OhnoLaboratory for Intestinal Ecosystem, Riken Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Satoru FukiyaResearch Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan.
Atsushi YokotaResearch Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan.
Mamoru NishimotoInstitute of Food Research, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan.
Motomitsu KitaokaFaculty of Agriculture, Niigata University, Niigata, Japan.
Hiroyuki NakaiFaculty of Agriculture, Niigata University, Niigata, Japan.
Shin KuriharaResearch Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.
Ishikawa Prefectural University · JPNiigata University · JPHokkaido University · JPKindai University · JPKyoto University · JPOsaka University · JPRIKEN Center for Integrative Medical Sciences · JPKanazawa University Hospital · JPNational Agriculture and Food Research Organization · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Certain existing prebiotics meant to facilitate the growth of beneficial bacteria in the intestine also promote the growth of other prominent bacteria. Therefore, the growth-promoting effects of β-galactosides on intestinal bacteria were analyzed. Galactosyl-β1,4-l-rhamnose (Gal-β1,4-Rha) selectively promoted the growth of

Indexed as

AnimalsATP-Binding Cassette TransportersBifidobacteriumBifidobacterium longum subspecies infantisClostridioides difficileDisaccharidesGastrointestinal MicrobiomeHumansIntestinesMaleMiceMice, Inbred C57BLPrebioticsATP-Binding Cassette TransportersDisaccharidesgalactosylrhamnosePrebioticsbifidobacteriaClostridioides difficilemicrobiomemicrobiotaPrebioticprobiotic

Identifiers

PMID34553672
PMCPMC8475593
OpenAlexW3199398362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.