Evidence map›Paper›PMID 34553411›Full record

ArticleJournal of cellular biochemistry2021

Cytotoxic effect of carbohydrate derivatives of digitoxigenin involves modulation of plasma membrane Ca

Jéssica Martins de Moura Valadares, Sumit O Bajaj, Hongyan Li, Hua-Yu L Wang, Simone Cavalcante Silva, Israel José Pereira Garcia, Duane Gischewiski Pereira, Pedro Azalim, Luis Eduardo Menezes Quintas, François Noël and 3 more

Open access · greenAbstract read
In one paragraph

Article in Journal of cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Chemical communications (Cambridge, England) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Jéssica Martins de Moura ValadaresCampus Centro-Oeste Dona Lindú, Laboratório de Bioquímica Celular, Universidade Federal de São João Del-Rei, Divinópolis, Minas Gerais, Brazil.ORCID 0000-0002-9934-2793
Sumit O BajajDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.ORCID 0000-0003-4621-3055
Hongyan LiDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.ORCID 0000-0002-7073-5198
Hua-Yu L WangDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.ORCID 0000-0002-2727-9537
Simone Cavalcante SilvaDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.ORCID 0000-0002-0257-7546
Israel José Pereira GarciaCampus Centro-Oeste Dona Lindú, Laboratório de Bioquímica Celular, Universidade Federal de São João Del-Rei, Divinópolis, Minas Gerais, Brazil.ORCID 0000-0002-4972-6561
Duane Gischewiski PereiraCampus Centro-Oeste Dona Lindú, Laboratório de Bioquímica Celular, Universidade Federal de São João Del-Rei, Divinópolis, Minas Gerais, Brazil.ORCID 0000-0001-8353-761X
Pedro AzalimInstituto de Ciências Biomédicas, Laboratório de Farmacologia Bioquímica e Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, State of Rio de Janeiro, Brazil.ORCID 0000-0003-3272-4321
Luis Eduardo Menezes QuintasInstituto de Ciências Biomédicas, Laboratório de Farmacologia Bioquímica e Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, State of Rio de Janeiro, Brazil.ORCID 0000-0002-0767-1240
François NoëlInstituto de Ciências Biomédicas, Laboratório de Farmacologia Bioquímica e Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, State of Rio de Janeiro, Brazil.ORCID 0000-0001-6813-1347
Vanessa Faria CortesCampus Centro-Oeste Dona Lindú, Laboratório de Bioquímica Celular, Universidade Federal de São João Del-Rei, Divinópolis, Minas Gerais, Brazil.ORCID 0000-0002-6464-7634
George Augustine O'DohertyDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.ORCID 0000-0002-1699-2249
Leandro Augusto BarbosaCampus Centro-Oeste Dona Lindú, Laboratório de Bioquímica Celular, Universidade Federal de São João Del-Rei, Divinópolis, Minas Gerais, Brazil.ORCID 0000-0002-4631-0130
Federal University of São João del-Rei · BRNortheastern University · USUniversidade Federal do Rio de Janeiro · BR

Funding

Apramycin scaffold exploration using novel glycochemistry and SAR studies to enhance activity against Acinetobacter baumannii and other multidrug-resistant Gram-negative pathogensR21AI142040 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIRBY, JAMES E, O'DOHERTY, GEORGE A · 2019 to 2020
$476k
Fusidic acid derivatization to enhance entry into Gram-negative pathogensR21AI146485 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIRBY, JAMES E, O'DOHERTY, GEORGE A · 2019 to 2020
$475k
Targeted modification of the apramycin 2-deoxystreptamine ring to block aminoglycoside modifying enzyme-based inactivation and enhance potency against multidrug-resistant Gram-negative pathogensR03AI144196 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIRBY, JAMES E, O'DOHERTY, GEORGE A · 2019 to 2020
$183k
NIAID NIH HHS R03 AI144196NIAID NIH HHS R21 AI142040NIAID NIH HHS R21 AI146485NIH HHS AI142040NIH HHS AI144196NIH HHS AI146485
6 · The paper itself

Abstract

Cardiac glycosides, such as digoxin and digitoxin, are compounds that interact with Na

Indexed as

DigitoxigeninCell MembraneHeLa CellsHumansPlasma Membrane Calcium-Transporting ATPasesSarcoplasmic Reticulum Calcium-Transporting ATPasesSodium-Potassium-Exchanging ATPaseDigitoxigeninPlasma Membrane Calcium-Transporting ATPasesSarcoplasmic Reticulum Calcium-Transporting ATPasesSodium-Potassium-Exchanging ATPasecardiac glycosidesdigitoxindigoxinHeLa cellsP-type ATPasessodium-potassium-exchanging ATPase

Identifiers

PMID34553411
PMCPMC8671332
OpenAlexW3199708590

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.