Evidence map›Paper›PMID 34553324›Full record

ArticleTranslational stroke research2022

A Novel Plant-Produced Asialo-rhuEPO Protects Brain from Ischemic Damage Without Erythropoietic Action.

Maotao He, Farooqahmed S Kittur, Chiu-Yueh Hung, Jianhui Zhang, Li Jing, David C Sane, P Andy Li, Jiahua Xie

Open access · greenAbstract read
In one paragraph

Article in Translational stroke research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Maotao He *Department of Pharmaceutical Sciences, Biomanufacturing Research Institute & Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA.
Farooqahmed S Kittur *Department of Pharmaceutical Sciences, Biomanufacturing Research Institute & Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA.
Chiu-Yueh HungDepartment of Pharmaceutical Sciences, Biomanufacturing Research Institute & Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA.
Jianhui ZhangDepartment of Pharmaceutical Sciences, Biomanufacturing Research Institute & Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA.
Li JingDepartment of Pathology, Ningxia Medical University, Yinchuan, 750004, China.
David C SaneCarilion Clinic and Virginia Tech Carilion School of Medicine, Roanoke, VA, 24014, USA.
P Andy LiDepartment of Pharmaceutical Sciences, Biomanufacturing Research Institute & Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA. pli@nccu.edu.ORCID 0000-0002-8712-3147
Jiahua XieDepartment of Pharmaceutical Sciences, Biomanufacturing Research Institute & Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA. jxie@nccu.edu.
North Carolina Central University · USCarilion Clinic · USNingxia Medical University · CNWeifang Medical University · CN

Funding

In Vivo Neuroprotective Properties and Action Mechanism(s) of Plant-produced Asialo-erythropoietinSC1GM111178 · NIGMS · NORTH CAROLINA CENTRAL UNIVERSITY · PI XIE, JIAHUA · 2017 to 2024
$2.9M
NIGMS NIH HHS SC1 GM111178
6 · The paper itself

Abstract

Mammalian cell-produced recombinant human erythropoietin (rhuEPO

Indexed as

ErythropoietinNeuroprotective AgentsStrokeAnimalsBrainMammalsMiceRecombinant ProteinsErythropoietinNeuroprotective AgentsRecombinant ProteinsAsialo-rhuEPOCerebral ischemiaMitochondrial fission and fusion proteinsMultimodal neuroprotectantNon-erythropoieticNon-immunogenic

Identifiers

PMID34553324
PMCPMC10068895
OpenAlexW3199248749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.