Evidence map›Paper›PMID 34553154›Full record

ArticleF&S reports2021

Case report: two cases of mature oocytes found in prepubertal girls during ovarian tissue cryopreservation.

Sarina N Hanfling, Toral Parikh, Allison Mayhew, Erin Robinson, James Graham, Veronica Gomez-Lobo, Jacqueline Y Maher

Open access · goldAbstract read
In one paragraph

Article in F&S reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Mature oocyte found during ovarian tissue cryopreservation in an early adolescent female.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Article
  3. Review
  4. Article
  5. Fertility preservation strategies for cancerous women: An updated review.Turkish journal of obstetrics and gynecology · 2022
    Article
  6. Review
  7. Single-Cell Transcriptomics Analysis of Human Small Antral Follicles.International journal of molecular sciences · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sarina N HanflingEunice Kennedy Shriver National Institute of Child Health and Human Development, Pediatric and Adolescent Gynecology Division, Bethesda, Maryland.
Toral ParikhAdvantage Women's Care, North Spring, Texas.
Allison MayhewEunice Kennedy Shriver National Institute of Child Health and Human Development, Pediatric and Adolescent Gynecology Division, Bethesda, Maryland.
Erin RobinsonShady Grove Fertility, Rockville, Maryland.
James GrahamShady Grove Fertility, Rockville, Maryland.
Veronica Gomez-LoboEunice Kennedy Shriver National Institute of Child Health and Human Development, Pediatric and Adolescent Gynecology Division, Bethesda, Maryland.
Jacqueline Y MaherEunice Kennedy Shriver National Institute of Child Health and Human Development, Pediatric and Adolescent Gynecology Division, Bethesda, Maryland.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USShady Grove Fertility Center · USWomen’s Health Care · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo report two cases of mature oocytes found in prepubertal girls undergoing ovarian tissue cryopreservation (OTC).

designCase report.

settingLarge tertiary care children's hospital and a private fertility clinic. PATIENTS: An 8-year-old prepubertal girl with β-thalassemia and a 2-year-old girl with sickle cell disease who both underwent OTC before bone marrow transplantations.

interventionsLaparoscopic right oophorectomy was performed in each patient. The ovarian cortical tissue was processed for slow freezing and long-term storage, and all oocytes were subsequently vitrified.

main outcome measuresOocytes found at the time of OTC processing for fertility preservation.

resultsAfter a complete right oophorectomy, one mature metaphase II oocyte was discovered on tissue processing for OTC in each patient. Neither patient has yet returned for use of tissue or oocytes.

conclusionsTo our knowledge, this is the first report of mature oocytes found during prepubertal OTC processing. These findings may indicate the need for increased research regarding prepubertal oocyte development and suggest that the technique of examining the media for both mature and immature oocytes at the time of OTC should become more widespread and perhaps recommended in prepubertal patients to optimize fertility preservation methods.

Indexed as

fertility preservationIVMoocyteOTCprepubertal ovary

Identifiers

PMID34553154
PMCPMC8441562
OpenAlexW3156838328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.