ArticleFunction (Oxford, England)2021
Secondhand Smoke Exposure Impairs Ion Channel Function and Contractility of Mesenteric Arteries.
Article in Function (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- CaThe Journal of physiology · 2026Article
- Amyloid β alters vascular CaThe Journal of physiology · 2025Article
- Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia.Circulation research · 2025Article
- Inverse association between pre-high-altitude potassium levels and coronary microvascular disease at high altitude: a case-control study.Frontiers in pharmacology · 2025Article
- α1Journal of the American Heart Association · 2024Article
- Nicotine Impairs Smooth Muscle cAMP Signaling and Vascular Reactivity.Microcirculation (New York, N.Y. : 1994) · 2024Article
- Global burden of stroke attributable to secondhand smoke in 204 countries and territories from 1990 to 2019: analysis of the global burden of disease study.Frontiers in neurology · 2024Article
- Effects of chronic secondhand smoke exposure on cardiovascular regulation and the role of soluble epoxide hydrolase in mice.Frontiers in physiology · 2023Article
- Diabetes and Excess Aldosterone Promote Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2022Article
- Spatiotemporal Control of Vascular CaCirculation research · 2022Article
- Mechanisms and physiological implications of cooperative gating of clustered ion channels.Physiological reviews · 2022Review
- Enhanced Vascular Contractility Following Secondhand Smoke Exposure: A Pathological "Double-hit" to Critical Smooth Muscle Ion Channels.Function (Oxford, England) · 2022Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
Cigarette smoke, including secondhand smoke (SHS), has significant detrimental vascular effects, but its effects on myogenic tone of small resistance arteries and the underlying mechanisms are understudied. Although it is apparent that SHS contributes to endothelial dysfunction, much less is known about how this toxicant alters arterial myocyte contraction, leading to alterations in myogenic tone. The study's goal is to determine the effects of SHS on mesenteric arterial myocyte contractility and excitability. C57BL/6J male mice were randomly assigned to either filtered air (FA) or SHS (6 h/d, 5 d/wk) exposed groups for a 4, 8, or 12-weeks period. Third and fourth-order mesenteric arteries and arterial myocytes were acutely isolated and evaluated with pressure myography and patch clamp electrophysiology, respectively. Myogenic tone was found to be elevated in mesenteric arteries from mice exposed to SHS for 12 wk but not for 4 or 8 wk. These results were correlated with an increase in L-type Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.