ArticleAging medicine (Milton (N.S.W))2019
Plasma levels of adiponectin and chemerin are associated with early stage of atherosclerosis in older adults with type 2 diabetes mellitus.
Article in Aging medicine (Milton (N.S.W)), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Chemerin and Arterial Stiffness in the Brisighella Heart Study: A Residual-Based Discordance Analysis.International journal of molecular sciences · 2026Article
- Impacts of Chemerin Levels and Antioxidant Capacity on the Severity of Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes and Prediabetes.Biomedicines · 2023Article
- The Role of Adipokines in the Pathogenesis of Psoriasis.International journal of molecular sciences · 2023Review
- Changes in adipokine levels and metabolic profiles following bariatric surgery.BMC endocrine disorders · 2022Article
- Plasma levels of adiponectin and chemerin are associated with early stage of atherosclerosis in older adults with type 2 diabetes mellitus.Aging medicine (Milton (N.S.W)) · 2019Article
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Authors and funding
5 authors.
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Abstract
objectiveAdipokines, such as adiponectin and chemerin, regulate fat metabolism and are critical for the development of atherosclerosis. Investigating the correlations of adiponectin and chemerin with atherosclerosis in older adults with type 2 diabetes mellitus (T2DM) will shed light on the search for new markers for early diagnosis of diabetic atherosclerosis.
methodsA total of 120 older T2DM patients and nine healthy controls were enrolled in this study. The clinical parameters, such as brachial-ankle pulse wave velocity (ba-PWV), adiponectin, and chemerin, were examined and recorded. T2DM subjects were divided into three groups according to ba-PWV level (high, medium, or low). The data were processed and analyzed by identical methods.
resultsSignificantly higher chemerin and lower adiponectin levels were detected in the plasma of T2DM patients than in healthy controls. The plasma levels of chemerin and adiponectin were negatively correlated in T2DM patients. Moreover, chemerin and adiponectin were significantly correlated with body mass index, ankle-brachial index, insulin, and ba-PWV. Multiple linear regression analysis revealed that chemerin and adiponectin were independently affecting ba-PWV.
conclusionAdiponectin and chemerin are potential markers for diagnosis and monitoring of early stage of atherosclerosis in older adults with T2DM. Further clinical investigations are required to confirm these markers.
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