ArticleBioMed research international2021
Radiomics Feature Analysis of Cartilage and Subchondral Bone in Differentiating Knees Predisposed to Posttraumatic Osteoarthritis after Anterior Cruciate Ligament Reconstruction from Healthy Knees.
Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The use of radiomic analysis of magnetic resonance imaging findings in predicting features of early osteoarthritis of the knee-a systematic review and meta-analysis.Irish journal of medical science · 2024Pooled it
- Soft tissue degeneration 10+ years after ACLR and their association with radiographic PTOA and knee pain development: radiomic analysis using qMRI approach in MOON nested on-site cohort.Osteoarthritis imaging · 2026Article
- Bayesian Graphical Models for Multiscale Inference in Medical Image-Based Joint Degeneration Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Radiomic features of infrapatellar fat pad are associated with knee symptoms and radiographic post-traumatic osteoarthritis at 10+ years after anterior cruciate ligament reconstruction.Osteoarthritis imaging · 2025Article
- Progress in multi-omics studies of osteoarthritis.Biomarker research · 2025Review
- Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside.Aging and disease · 2024Review
- Dual-energy computed tomography-based radiomics for differentiating patients with and without gout flares.Clinical rheumatology · 2024Article
- Radiomics signature of osteoarthritis: Current status and perspective.Journal of orthopaedic translation · 2024Review
- Determining rib fracture age from CT scans with a radiomics-based combined model: a multicenter retrospective study.Insights into imaging · 2023Article
- Radiomics‑Clinical model based onJournal of cancer research and clinical oncology · 2023Article
- Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review.Osteoarthritis and cartilage open · 2023Review
- Quantitative evaluation of the infrapatellar fat pad in knee osteoarthritis: MRI-based radiomic signature.BMC musculoskeletal disorders · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo introduce a new implementation of radiomics analysis for cartilage and subchondral bone of the knee and to compare the performance of the proposed models to classic T2 relaxation time in distinguishing knees predisposed to posttraumatic osteoarthritis (PTOA) after anterior cruciate ligament reconstruction (ACLR) and healthy controls.
methods114 patients following ACLR after at least 2 years and 43 healthy controls were reviewed and allocated to training (
resultsThe T2 value model of cartilage yielded moderate predictive performance in discerning patients and controls, with an AUC of 0.731 (95% confidence interval, 0.556-0.875) in the testing cohort, while the radiomics signature of cartilage and subchondral bone of different compartments demonstrated excellent performance, with AUCs of 0.864-0.979. Furthermore, the combined model reported an even better performance, with AUCs of 0.977 (95% confidence interval, 0.919-1.000) for the cartilage and 0.934 (95% confidence interval, 0.865-0.994) for the subchondral bone in the testing cohort.
conclusionThe radiomics features of the cartilage and subchondral bone may be able to provide powerful tools with more sensitive detection than T2 values in differentiating knees at risk for PTOA after ACLR from healthy knees.
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