Evidence map›Paper›PMID 34552950›Full record

ArticleFrontiers in medicine2021

Heterologous Hyperimmune Polyclonal Antibodies Against SARS-CoV-2: A Broad Coverage, Affordable, and Scalable Potential Immunotherapy for COVID-19.

Alberto Alape-Girón, Andrés Moreira-Soto, Mauricio Arguedas, Hebleen Brenes, Willem Buján, Eugenia Corrales-Aguilar, Cecilia Díaz, Ann Echeverri, Marietta Flores-Díaz, Aarón Gómez and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Equine immunoglobulin fragment F(ab')Clinical immunology (Orlando, Fla.) · 2022
    Article
  5. Anti-SARS-CoV-2 equine F (Ab')Scientific reports · 2022
    Article
  6. Review
  7. UsingExpert opinion on drug discovery · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Alberto Alape-GirónInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Andrés Moreira-SotoInstitute of Virology, Charité Medical University of Berlin, Berlin, Germany.
Mauricio ArguedasInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Hebleen BrenesInstituto Costarricense de Investigación y Enseñanza en Nutrición y Salud, Ministry of Health, Cartago, Costa Rica.
Willem BujánSchool of Medicine University of Costa Rica, San Pedro, Costa Rica.
Eugenia Corrales-AguilarResearch Center for Tropical Diseases, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Cecilia DíazInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Ann EcheverriCaja Costarricense del Seguro Social, San Jose, Costa Rica.
Marietta Flores-DíazInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Aarón GómezInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Andrés HernándezInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
María HerreraInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Guillermo LeónInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Román MacayaCaja Costarricense del Seguro Social, San Jose, Costa Rica.
José Arturo Molina-MoraResearch Center for Tropical Diseases, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Javier MoraResearch Center for Tropical Diseases, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Aarthi NarayananNational Center for Biodefense and Infectious Diseases, College of Science, George Mason University, Fairfax, VA, United States.
Alfredo SanabriaCaja Costarricense del Seguro Social, San Jose, Costa Rica.
Andrés SánchezInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Laura SánchezInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Álvaro SeguraInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Eduardo SeguraInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Daniela SolanoInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Claudio SotoInstituto Costarricense de Investigación y Enseñanza en Nutrición y Salud, Ministry of Health, Cartago, Costa Rica.
Jennifer L StynoskiInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Mariángela VargasInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Mauren VillaltaInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
Jan Felix DrexlerInstitute of Virology, Charité Medical University of Berlin, Berlin, Germany.
José María GutiérrezInstituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

convalescent plasmaCOVID-19heterologous antibodieshyperimmune polyclonal antibodiesmonoclonal antibodiespassive immunotherapySARS-CoV-2

Identifiers

PMID34552950
PMCPMC8450768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.