Evidence map›Paper›PMID 34552873›Full record

ArticleFrontiers in oncology2021

The Ratio of Preoperative Serum Biomarkers Predicts Prognosis in Patients With Oral Squamous Cell Carcinoma.

Meng Ding, Yuxian Song, Junyan Jing, Mei Tian, Liang Ding, Qiang Li, Chongchong Zhou, Heng Dong, Yanhong Ni, Yongbin Mou

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In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. The Role of Proinflammatory Biomarkers in Oral Cancer Pathophysiology.Advances in experimental medicine and biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meng DingNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
Yuxian SongCentral Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
Junyan JingDepartment of Oral Implantology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
Mei TianNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
Liang DingCentral Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
Qiang LiDepartment of Oral Implantology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
Chongchong ZhouNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
Heng DongDepartment of Oral Implantology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
Yanhong NiCentral Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
Yongbin MouDepartment of Oral Implantology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDynamic changes in circulating immune-inflammatory cells have been regarded as simple and convenient prognostic biomarkers in various cancers. However, studies on the prognostic values of their ratios in oral squamous cell carcinoma (OSCC) remain limited. MATERIALS AND

methodsA total of 493 OSCC patients were included in the present study. Here, we investigated the prognostic values of the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-white blood cell ratio (NWR), and lymphocyte-to-white blood cell ratio (LWR) in OSCC. The correlations of the NLR, LMR, NWR, and LWR with clinicopathological characteristics were statistically analyzed using the Chi-square test, Kaplan-Meier curves, and univariate and multivariate Cox regression models.

resultKaplan-Meier analyses revealed that OSCC patients with a high LMR and low NWR had prolonged overall survival (OS,

conclusionPreoperative NLR, LMR, NWR, and LWR in the peripheral blood are significant prognostic factors for OSCC and might be helpful in predicting OSCC progression.

Indexed as

disease-free survivallymphocyte-to-monocyte ratiolymphocyte-to-white blood cell ratiometastasis-free survivalneutrophil-to-lymphocyte rationeutrophil-to-white blood cell ratiooral squamous cell carcinomaoverall survival

Identifiers

PMID34552873
PMCPMC8452155

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.