Evidence map›Paper›PMID 34552826›Full record

ArticleACS sustainable chemistry & engineering2021

Fate of a Deep Eutectic Solvent upon Cosolvent Addition: Choline Chloride-Sesamol 1:3 Mixtures with Methanol.

Matteo Busato, Alessandra Del Giudice, Valerio Di Lisio, Pierpaolo Tomai, Valentina Migliorati, Alessandra Gentili, Andrea Martinelli, Paola D'Angelo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS sustainable chemistry & engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Matteo BusatoDepartment of Chemistry, University of Rome "La Sapienza", P.le A. Moro 5, 00185 Rome, Italy.ORCID https://orcid.org/0000-0002-9450-0481
Alessandra Del GiudiceDepartment of Chemistry, University of Rome "La Sapienza", P.le A. Moro 5, 00185 Rome, Italy.ORCID https://orcid.org/0000-0002-1916-8300
Valerio Di LisioDepartment of Chemistry, University of Rome "La Sapienza", P.le A. Moro 5, 00185 Rome, Italy.
Pierpaolo TomaiDepartment of Chemistry, University of Rome "La Sapienza", P.le A. Moro 5, 00185 Rome, Italy.
Valentina MiglioratiDepartment of Chemistry, University of Rome "La Sapienza", P.le A. Moro 5, 00185 Rome, Italy.ORCID https://orcid.org/0000-0003-4733-6188
Alessandra GentiliDepartment of Chemistry, University of Rome "La Sapienza", P.le A. Moro 5, 00185 Rome, Italy.ORCID https://orcid.org/0000-0002-9541-3857
Andrea MartinelliDepartment of Chemistry, University of Rome "La Sapienza", P.le A. Moro 5, 00185 Rome, Italy.ORCID https://orcid.org/0000-0002-6401-9988
Paola D'AngeloDepartment of Chemistry, University of Rome "La Sapienza", P.le A. Moro 5, 00185 Rome, Italy.ORCID https://orcid.org/0000-0001-5015-8410
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The changes upon methanol (MeOH) addition in the structural arrangement of the highly eco-friendly deep eutectic solvent (DES) formed by choline chloride (ChCl) and sesamol in 1:3 molar ratio have been studied by means of attenuated total reflection Fourier transform infrared spectroscopy, small- and wide-angle X-ray scattering (SWAXS), and molecular dynamics simulations. The introduction of MeOH into the DES promotes the increase of the number of Cl-MeOH hydrogen bonds (HBs) through the replacement of sesamol and choline molecules from the chloride anion coordination sphere. This effect does not promote the sesamol-sesamol, choline-choline, and sesamol-choline interactions, which remain as negligible as in the pure DES. Differently, the displaced sesamol and choline molecules are solvated by MeOH, which also forms HBs with other MeOH molecules, so that the system arranges itself to keep the overall amount of HBs maximized. SWAXS measurements show that this mechanism is predominant up to MeOH/DES molar ratios of 20-24, while after this ratio value, the scattering profile is progressively diluted in the cosolvent background and decreases toward the signal of pure MeOH. The ability of MeOH to interplay with all of the DES components produces mixtures with neither segregation of the components at nanoscale lengths nor macroscopic phase separation even for high MeOH contents. These findings have important implications for application purposes since the understanding of the pseudophase aggregates formed by a DES with a dispersing cosolvent can help in addressing an efficient extraction procedure.

Identifiers

PMID34552826
PMCPMC8442355
OpenAlexW3197872021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.