Evidence map›Paper›PMID 34552825›Full record

ArticleOncoimmunology2021

Hsp70 modulates immune response in pancreatic cancer through dendritic cells.

Bhuwan Giri, Prateek Sharma, Tejeshwar Jain, Anthony Ferrantella, Utpreksha Vaish, Siddharth Mehra, Bharti Garg, Srikanth Iyer, Vrishketan Sethi, Zoe Malchiodi and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Bhuwan GiriDeWitt Daughtry Family Department of Surgery, University of Miami, Coral Gables, FL, USA.
Prateek SharmaDivision of Surgical Oncology, Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL, USA.
Tejeshwar JainDivision of Surgical Oncology, Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL, USA.
Anthony FerrantellaDeWitt Daughtry Family Department of Surgery, University of Miami, Coral Gables, FL, USA.
Utpreksha VaishDivision of Surgical Oncology, Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL, USA.
Siddharth MehraDeWitt Daughtry Family Department of Surgery, University of Miami, Coral Gables, FL, USA.
Bharti GargDeWitt Daughtry Family Department of Surgery, University of Miami, Coral Gables, FL, USA.
Srikanth IyerDivision of Surgical Oncology, Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL, USA.
Vrishketan SethiDivision of Surgical Oncology, Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL, USA.
Zoe MalchiodiDeWitt Daughtry Family Department of Surgery, University of Miami, Coral Gables, FL, USA.
Rossana SignorelliDeWitt Daughtry Family Department of Surgery, University of Miami, Coral Gables, FL, USA.
Harrys K C JacobDeWitt Daughtry Family Department of Surgery, University of Miami, Coral Gables, FL, USA.
John GeorgeDeWitt Daughtry Family Department of Surgery, University of Miami, Coral Gables, FL, USA.
Preeti SahayDivision of Surgical Oncology, Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL, USA.
Ejas P BavaDivision of Surgical Oncology, Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL, USA.
Rajinder DawraDeWitt Daughtry Family Department of Surgery, University of Miami, Coral Gables, FL, USA.
Sundaram RamakrishnanDeWitt Daughtry Family Department of Surgery, University of Miami, Coral Gables, FL, USA.
Ashok SalujaDeWitt Daughtry Family Department of Surgery, University of Miami, Coral Gables, FL, USA.
Vikas DudejaDivision of Surgical Oncology, Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL, USA.
University of Miami · USUniversity of Alabama at Birmingham · US

Funding

Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI George S. Grills · 2019 to 2026
$24.1M
The Inhibition of HSP70 Induces Apoptosis in Pancreatic Cancer CellsR01CA124723 · NCI · UNIVERSITY OF MINNESOTA · PI GILBOA, ELI, RAMAKRISHNAN, SUNDARAM · 2007 to 2022
$4.5M
Therapeutic efficacy of Pirfenidone in PancreatitisR01DK111834 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DUDEJA, VIKAS · 2017 to 2020
$1.4M
NCI NIH HHS P30 CA240139NCI NIH HHS R01 CA124723NIDDK NIH HHS R01 DK111834
6 · The paper itself

Abstract

Heat shock protein 70 (Hsp70), a protein chaperone, is known to promote cell survival and tumor progression. However, its role in the tumor microenvironment (TME) is largely unknown. We specifically evaluated Hsp70 in the TME by implanting tumors in wild-type (WT) controls or Hsp70

Indexed as

HSP70 Heat-Shock ProteinsPancreatic NeoplasmsAnimalsCD8-Positive T-LymphocytesDendritic CellsLymphocyte ActivationMiceTumor MicroenvironmentHSP70 Heat-Shock Proteinsdendritic cellsHsp70immunotherapyPancreatic cancerstroma

Identifiers

PMID34552825
PMCPMC8451449
OpenAlexW3201617218

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.