Evidence map›Paper›PMID 34552688›Full record

ArticleOxidative medicine and cellular longevity2021

Lipidomic Alterations and PPAR

Zhengyun Chen, Chunyan Wang, Cuicui Lin, Lifeng Zhang, Huimei Zheng, Yong Zhou, Xiaoyong Li, Chen Li, Xinmei Zhang, Xiaohang Yang and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  12. Transgenic mice applications in the study of endometriosis pathogenesis.Frontiers in cell and developmental biology · 2024
    Review
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  15. The Phytochemical Profile and Biological Activity ofMolecules (Basel, Switzerland) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Zhengyun ChenThe Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.ORCID https://orcid.org/0000-0002-2121-0723
Chunyan WangThe Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.ORCID https://orcid.org/0000-0001-5421-5929
Cuicui LinThe Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.ORCID https://orcid.org/0000-0002-5510-4486
Lifeng ZhangThe Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.ORCID https://orcid.org/0000-0002-1414-4043
Huimei ZhengThe Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.ORCID https://orcid.org/0000-0001-7129-8412
Yong ZhouThe Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.ORCID https://orcid.org/0000-0001-7812-8280
Xiaoyong LiThe Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.ORCID https://orcid.org/0000-0001-9778-8030
Chen LiThe Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.ORCID https://orcid.org/0000-0002-8014-6848
Xinmei ZhangThe Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.ORCID https://orcid.org/0000-0001-6834-7690
Xiaohang YangThe Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.ORCID https://orcid.org/0000-0001-5192-5706
Minxin GuanInstitute of Genetics, Zhejiang University, Hangzhou, Zhejiang 310058, China.ORCID https://orcid.org/0000-0001-5067-6736
Yongmei XiThe Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.ORCID https://orcid.org/0000-0001-7374-2564
Women's Hospital, School of Medicine, Zhejiang University · CNChildren's Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometriosis is an estrogen-dependent chronic inflammatory disease that affects approximately 10% of women of reproductive age and up to 50% of women with infertility. The heterogeneity of the disease makes accurate diagnosis and treatment a clinical challenge. In this study, we generated two models of endometriosis: the first in rats and the second using human ectopic endometrial stromal cells (HEcESCs) derived from the lesion tissues of endometriosis patients. We then applied resveratrol to assess its therapeutic potential. Resveratrol intervention had significant efficacy to attenuate lesion size and to rectify aberrant lipid profiles of model rats. Lipidomic analysis revealed significant lipidomic alterations, including notable increases of sphingolipids and decreases of both glycerolipids and most phospholipids. Upon resveratrol application, both proliferation capacity and invasiveness parameters decreased, and the early apoptosis proportion increased for HEcESCs. The activation of PPAR

Indexed as

AnimalsAntioxidantsApoptosisDisease Models, AnimalEndometriosisEndometriumFemaleGene Expression ProfilingHumansLipid MetabolismLipidomicsPPAR alphaRatsRats, Sprague-DawleyResveratrolStromal CellsAntioxidantsPPAR alphaResveratrol

Identifiers

PMID34552688
PMCPMC8452402
OpenAlexW3201446103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.